p53-mediated protective responses to UV irradiation - PNAS
1997年11月11日 · Mutant p53 genes isolated from nonmelanoma skin cancers and premalignant lesions exhibit characteristic “fingerprint” mutations associated with UV damage, consisting of …
p53 dynamics vary between tissues and are linked with radiation ...
2021年2月9日 · We find that radiosensitive tissues show prolonged p53 signaling after radiation, while more resistant tissues show transient p53 activation. Sustaining p53 using a small …
Sublethal UV irradiation induces squamous differentiation via a p53 …
2018年10月25日 · We irradiated human primary control or p53 knock-down keratinocytes at lethal doses (lthUV, 150-300mJ/cm 2) or sbUV doses of UV. p53 protein and mRNA were …
Cellular UV damage responses—Functions of tumor suppressor p53
2005年7月25日 · p53 UV response. When cells are exposed to UV radiation, p53 accumulates due to the stalling of transcription machinery and/or nucleolar disruption. p53 activity is …
UV-radiation induces dose-dependent regulation of p53 response …
2001年10月19日 · Low amounts of UVB/C-radiation induced a transient cell cycle arrest of the cells which correlated with rapid but transient increase in p53 levels. In contrast, high UV …
The Tumor Suppressor p53 Can Both Stimulate and Inhibit …
Using a stable human cell line expressing a murine temperature-sensitive p53 in which p53 function could be tightly and reversibly regulated, we found that functional p53 stimulated the …
p53-Mediated DNA Repair Responses to UV Radiation: Studies of …
Human cells lacking functional p53 exhibit a partial deficiency in nucleotide excision repair (NER), the pathway for repair of UV-induced DNA damage. The global genomic repair (GGR) …
Absence of p53-dependent apoptosis leads to UV radiation ...
In this study, we found that mice harboring a hypomorphic mutant p53, R172P, a mutation that abrogates p53-mediated apoptosis while keeping cell cycle control mostly intact, are more …
Role of p53 in Regulating Radiation Responses - PMC - PubMed …
p53 is known as the guardian of the genome and plays various roles in DNA damage and cancer suppression. The p53 gene was found to express multiple p53 splice variants (isoforms) in a …
Role and regulation of p53 during an ultraviolet radiation
p53 can play a key role in response to DNA damage by activating a G1 cell cycle arrest. However, the importance of p53 in the cell cycle response to UV radiation is unclear. In this study, we …