2013年3月1日 · Here we provide insights from in vitro experiments and in vivo xenotransplantation assays that highlight a dual role for p53 in regulating VEGF during hypoxia.

Our analysis demonstrates statistically significant increases in VEGFA mRNA tissue expression in TP53 -mutated adenocarcinomas (but not in squamous cancers) compared to TP53 wild-type tumors. This association holds true in multivariate analyses and remains independent of HIF-1α and MDM2 overexpression.

There is growing evidence that the p53 tumour suppressor downregulates vascular endothelial growth factor (VEGF) expression, although the underlying mechanisms remain unclear and controversial. Here we provide insights from in vitro experiments and in vivo xenotransplantation assays that highlight a …

2013年6月10日 · After 4 h of hypoxia (acute phase), p53 and HIF-1α induce VEGF transcription leading to a significant induction of mRNA. After 24 h (chronic phase) VEGF mRNA levels drop, but remain well...

We have shown that p53 can positively regulate VEGF expression during the initial phases of hypoxia by direct binding to conserved sites in the VEGF promoter. 3 It remains to be determined if p73 and dNp63 can synergistically act with HIF-1α in positively regulating VEGF expression during hypoxia by directly binding to this conserved site.

Unexpectedly, and for the first time, we demonstrate that p53 rapidly induces VEGF transcription upon hypoxia exposure by binding, in an HIF-1a-dependent manner, to a highly conserved and...

We aimed to evaluate the carcinogenesis risk in inflammatory bowel disease via p53 mutation and its relation with hyperproliferation (cyclin-D1) and angiogenesis (with vascular endothelial growth factor [VEGF] and microvessel density) and whether these events play important roles in pathogenesis of …

三阴性乳腺癌组织vegf、p53阳性表达者3年总存活率显著低于阴性患者，差异均具有统计学意义（p < 0.05）。结论：vegf、p53阳性表达与三阴性乳腺癌发生、进展、淋巴结转移及预后不良密切相关。

2001年12月1日 · In this paper, we found a strong, statistically significant association between expression of VEGF and the presence of a p53-gene mutation. The proportion of cases with a positive result of p53 mutation among patients with a low, intermediate and high VEGF expression increased statistically significantly from 20 to 53, and 78%, respectively.

2013年3月1日 · p53 induces VEGF transcription during the initial stages of hypoxia. Interpretation of the putative cross-talk between p53 and VEGF signalling has so far been complicated owing to the use of cancer cell lines that have accumulated many uncharacterized oncogenic lesions due to genomic instability.