2019年9月23日 · Results: We found that YAP promotes P53 deacetylation, promotes cell survival by inhibiting P53-induced G0/G1 arrest and apoptosis in A549 cells. Conversely, P53 enhances YAP acetylation, and decreases A549 cell survival by strengthening YAP acetylation-induced G0/G1 arrest and apoptosis both in vitro and in vivo.

2019年8月9日 · The YAP1/Hippo and p53 pathways are critical protectors of genome integrity in response to DNA damage. Together, these pathways secure cellular adaptation and maintain overall tissue integrity through transcriptional re-programing downstream of various environmental and biological cues generated dur …

YAP can directly bind to TP53 gene promoter and upregulate p53 expression leading to apoptosis during hepatocellular carcinoma chemotherapy. In turn, p53 can bind to the YAP promoter and upregulate YAP expression, establishing a positive feedback loop.

Collectively, our results demonstrated a novel tumour suppressor role of CYGB through p53-YAP1 axis in regulating ferroptosis and suggested a potential therapeutic approach for colon cancer.

2019年7月19日 · Here we show that β-arrestin1 (β-arr1), interacts with YAP, triggering its cytoplasmic-nuclear shuttling. This interaction allows β-arr1 to recruit mutp53 to the YAP-TEAD transcriptional complex...

2015年12月21日 · In search for co‐factors sharing mutant p53‐induced transcriptomic alterations in breast cancer cells, we identified the transcriptional co‐factor YAP1 (Yes‐associated protein) as a new partner of mutant p53 proteins in diverse types of tumors. YAP1 is an oncogene, amplified or hyperactivated in a number of human solid tumors.

11 小时之前 · The tumor suppressor protein p53 could revert the Warburg effect, and to negatively influence the oncogenic metabolic adaption of cancer cells 15.

We found that YAP promotes P53 deacetylation, promotes cell survival by inhibiting P53-induced G0/G1 arrest and apoptosis in A549 cells. Conversely, P53 enhances YAP acetylation, and decreases A549 cell survival by strengthening YAP acetylation-induced G0/G1 arrest and apoptosis both in vitro and in vivo.

2021年2月21日 · YAP1 was a key downstream target of CYGB through p53 regulation to promote ferroptotic cell death signalling pathway (Figure 7F). Thus, our findings emphasize the importance of CYGB in ferroptosis regulation in colon cancer cells.

In present study, we identified that mutant p53 pattern was a significant prognostic factor in breast cancer with low nuclear YAP1 expression (OS, HR 6.688, 95% CIs 2.187–20.45, P = 0.0009; RFS, HR 2.771, 95% CIs 1.501–5.115, P = 0.0011), and interestingly, mutant p53 pattern showed no prognostic effect on high YAP1 tumors.