The Cross Talk Between p53 and mTOR Pathways in Response to …
2021年11月18日 · In this review, we first briefly introduce the tumor suppressor p53 and then describe the upstream regulators and downstream effectors of the mTOR pathway. Next, we …
新成果｜Genes Dev：顾伟团队在p53-mTOR及铁死亡领域新突破
2020年12月24日 · 这些结果说明了p53除了通过诱导细胞凋亡，周期阻滞，衰老和铁死亡外，还可以通过mTOR pathway来抑制肿瘤的发展和胚胎发育。 为了研究p53在缺失凋亡，细胞周期阻 …
The Cross Talk Between p53 and mTOR Pathways in Response to ...
In this review, we first briefly introduce the tumor suppressor p53 and then describe the upstream regulators and downstream effectors of the mTOR pathway. Next, we discuss the role of p53 …
p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 …
2021年12月14日 · We provide evidence that DDIT4 is required for p53 to inhibit mTOR complex 2 (mTORC2)-dependent AKT activation. Most strikingly, we also find that the DDIT4 regulator …
The coordinate regulation of the p53 and mTOR pathways in cells
2005年6月7日 · The results presented here demonstrate that activation of p53 inhibits mTOR activity and regulates its downstream targets, including autophagy, a tumor suppression process.
顾伟实验室解析p53抑癌功能的终极武器——铁死亡和mTOR|细胞|蛋白|mtor…
2020年12月21日 · p53可以通过多种方式抑制mtor通路，其中诱导sestrin家族蛋白sens1和sens2，以及激活ddit4（也称为redd1）是两个重要途径。 果然，5KR p53相对于4KR丧失了 …
The coordinate regulation of the p53 and mTOR pathways in cells
2005年6月7日 · The results presented here demonstrate that activation of p53 inhibits mTOR activity and regulates its downstream targets, including autophagy, a tumor suppression …
mTOR inhibition acts as an unexpected checkpoint in p53 ... - PubMed
2021年1月1日 · Notably, the early-onset tumor formation observed in p53 5KR/5KR and p53-null mice was suppressed upon the treatment of the mTOR inhibitor. These results suggest that …
P53 and mTOR signalling determine fitness selection through cell ...
2018年5月2日 · Here we identify that in the early mouse embryo and upon exit from naive pluripotency, the confrontation of cells with different fitness levels leads to an inhibition of …
mTORC1 and p53: Clash of the gods? - PMC
The mTORC1 pathway governs a response to mitogenic signals with high energy levels to promote protein synthesis and cell growth. In contrast, the p53 DNA damage response …