P53 and TP53 are two terms often used interchangeably, but they have distinct differences in their attributes and functions. P53 refers to the protein encoded by the TP53 gene, which plays a crucial role in regulating cell division and preventing the formation of cancerous cells.

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …

p53和TP53有什么相似之处? TP53基因具有产生p53肿瘤抑制蛋白的遗传指令。 TP53和p53都是预防肿瘤发展所必需的。 p53积累和TP53突变是乳腺癌预后的标志。 此外，TP53基因突变导致突变p53蛋白的产生和积累。 p53和TP53有什么区别? p53是一种蛋白质，TP53是一种基因。

2022年3月31日 · While virtually all TP53 mutations are thought to compromise wild type p53 activity, the prevalence and recurrence of missense TP53 alleles has motivated countless research studies aimed at...

2024年12月25日 · TP53 (Tumor Protein P53) is a Protein Coding gene. Diseases associated with TP53 include Li-Fraumeni Syndrome and Papilloma Of Choroid Plexus. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Regulation of activated PAK-2p34 by proteasome mediated degradation.

TP53 is the most commonly mutated gene in human cancers. These mutations are primarily non-synonymous changes that produce mutant p53 proteins characterized by loss of function, a dominant negative effect on p53 tetramerisation and gain of function (GOF).

2024年7月21日 · 简单的说，就是TP53和TRP53是基因的叫法，分别是human和mice的，而他们表达的蛋白叫P53。p53是一种肿瘤抑制基因。该基因编码一种分子量为53kDa的蛋白质，命名为P53。p53基因的失活对肿瘤形成起重要作用。

2023年3月1日 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key structural features of...

The TP53 gene is one of the most commonly mutated genes in cancers, and its encoded protein, p53, is a DNA damage response regulator. Thereby, overcoming p53-induced cell-cycle arrest and cell death is one of the hallmarks of tumorigenesis.