SQSTM1/p62 is a prototype autophagy receptor, which is commonly found in protein aggregates associated with major neurodegenerative diseases. While accumulation of SQSTM1 …

Sequestosome 1/p62 Protein in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration SQSTM1 /p62, henceforth referred to as p62, is a scaffold protein that has roles …

2021年6月1日 · We found that stressors (proteasome inhibition and arsenic) increased p62 expression and that this shifted the nuclear:cytoplasmic TDP-43 ratio. Overall, our study …

2022年8月25日 · Our data demonstrate co-deposition of p62 with mutant and wild-type disSOD1 and phosphorylated TDP-43 in familial and sporadic ALS spinal cord motor neurons, …

Mutations in SQSTM1 encoding the sequestosome 1/p62 protein have recently been identified in familial and sporadic cases of amyotrophic lateral sclerosis (ALS). p62 is a component of the …

2018年5月29日 · Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Recent studies have …

SQSTM1/p62 是一种原型自噬受体，常见于与主要神经退行性疾病相关的蛋白质聚集体中。 虽然 SQSTM1 的积累涉及选择性自噬途径的紊乱，但导致自噬降解受损的致病机制仍然难以表征。 …

The results show that p62 accumulated in protein aggregates in G93A transgenic mice long before the disease onset, suggesting that p62 may be involved in the mutant SOD1-mediated …

2022年5月1日 · Mutations in the functional domains of p62 provide links to the pathogenetic mechanisms of p62 and dyshomeostasis of p62 levels is noted in several types of ALS and …

3 天之前 · Survival in sporadic ALS linked to autophagy protein p62. Blocking LDLR seen to prevent neurotoxic effects in mice. In the body, ApoB binds to two different receptor proteins …