Discovery of SQSTM1/p62-dependent P-bodies that
2024年3月26日 · Mechanistically, pd-PBs are triggered by enhanced p62 droplet formation upon stress stimulation through the interactions between p62 and DDX6, a DEAD-box ATPase. …
Discovery of SQSTM1/p62-dependent P-bodies that regulate the …
2024年3月26日 · Mechanistically, pd-PBs are triggered by enhanced p62 droplet formation upon stress stimulation through the interactions between p62 and DDX6, a DEAD-box ATPase. …
DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes
2017年7月25日 · Through a genome-wide genetic screen, we identified DEAD-box helicase 6 (DDX6) as a suppressor of ISGs. Genetic ablation of DDX6 induced global upregulation of …
Mecha-nistically, pd-PBs are triggered by enhanced p62 droplet formation upon stress stimulation through the in-teractions between p62 and DDX6, a DEAD-box ATPase. Functionally, pd-PBs …
Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to …
2019年8月21日 · We reveal that DAXX drives p62 liquid phase condensation by inducing p62 oligomerisation. The condensed p62 bodies efficiently recruit aberrant proteins and specific …
Inhibition of DDX6 enhances autophagy and alleviates …
2022年3月1日 · In this study, we investigated the role of DDX6 in PEDV replication and found that during PEDV infection, DDX6 was down-regulated and partially alleviates ER stress by …
Transformation of autophagic SQSTM1 droplets to SQSTM1 …
2024年4月10日 · With both polyubiquitin chains and SQSTM1, DDX6 undergoes rapid condensation and gelation in vitro. The reconstituted system suggests that SQSTM1 droplet …
胡红雨组揭示Ataxin-2蛋白通过募集RNA解旋酶DDX6影响细胞P-bo…
2024年6月28日 · PolyQ 延伸突变的 Atx2 在细胞中发生错误折叠形成积聚物，该积聚物募集细胞质中的 DDX6 ，导致细胞中可溶性 DDX6 的减少。 DDX6 量的减少损坏了细胞质中 P-body 的 …
Discovery of SQSTM1/p62-dependent P-bodies that regulate
2024年3月26日 · Mechanistically, pd-PBs are triggered by enhanced p62 droplet formation upon stress stimulation through the interactions between p62 and DDX6, a DEAD-box ATPase. …
P-body dynamics revealed by DDX6 protein knockdown via the
By introducing AID-tagged DDX6 and the E3 ligase subunit of OsTIR1 into ES cells, we successfully degraded DDX6 following auxin analog (indole-3-acetic acid, IAA) treatment. The …
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