2015年11月9日 · The addition of IL-6 to starved U937 cells significantly activated the phosphorylation level of STAT3 (p-STAT3) at Tyr705 and reduced the protein levels of microtubule-associated protein 1...

2024年3月5日 · Sequestosome 1 (p62 or SQSTM1) bodies are notable representatives of such degradation condensates, which bridge the gap between the ubiquitin–proteasome system (UPS) and the...

2024年10月7日 · This study demonstrated the capacity of p62 to monogenically regulate the obesity phenotype and emphasized its dual role in managing energy homeostasis through direct modulation of STAT3/POMC signaling and amplification of leptin sensitivity.

2024年10月7日 · In this study, we found that the deletion of p62 in hypothalamic POMC-positive neurons attenuated STAT3 phosphorylation, STAT3 translocation from the cytoplasm to the nucleus and decreased POMC neuron excitability, while the overexpression of p62 in POMC neurons had the opposite effect.

New data obtained from the laboratory of Guido Kroemer identifies STAT3 as a new autophagy regulator. In the cytoplasm, in the absence of conventional phosphorylation on the tyrosine 705 residue, STAT3 interacts with the PKR kinase to inhibit eIF2A phosphorylation and so reduce autophagic pathways.

2021年8月24日 · The regulation of apatinib on VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling were detected. Furthermore, we collected conditioned medium (CM) from A549 and H1299 cells to stimulate phorbol myristate acetate (PMA)-activated THP-1 cells, and examined the effect of apatinib on PD-L1 expression in macrophages.

2025年4月1日 · WTAP enhances the m6A modification level of STAT3, leading to decreased expression of STAT3, which activates mitochondrial autophagy and inhibits the activation of the NLRP3 signaling pathway. These biological changes help reduce inflammation and promote the recovery of neural functions following neuronal damage.

p62在自噬和过早衰老中都发挥着调节作用，它也是导致衰老相关分泌表型（sasp）的不可替代的分子和选择性自噬的底物。 本研究重点关注 STAT3， 材料和方法 4 Gy X线照射后，用β-半乳糖苷酶染色试剂盒检测早衰阳性率。

Our research has shown that X-ray irradiation induces premature senescence in lung adenocarcinoma cells, and its occurrence partially depends on the signal transducer and activator of transcription 3 (STAT3). STAT3 can bind to the promoter region of …

目的 探讨STAT3 和自噬相关蛋白Beclin1、p62、LC3B在结肠癌组织中的表达情况,并分析它们之间的相关性.方法 免疫组化方法检测结肠癌组织(n=86)、癌旁组织(n=86)及正常结肠组织(n= 86)包埋蜡块中 STAT3、Beclin1、p62、LC3B 的阳性表达率,并分析 STAT3 与自噬指标在结肠癌中 ...