p63 expression in human tumors and normal tissues: a tissue …
2021年1月25日 · Tumor protein 63 (p63) is a transcription factor of the p53 gene family encoded by the TP63 gene located at chromosome 3q28. p63 regulates the activity of a multitude of …
Alveolar regeneration by airway secretory-cell-derived p63 - Cell …
2024年11月7日 · Dual recombinase-mediated sequential genetic-lineage tracing demonstrates that p63 + progenitors originate from airway secretory cells and subsequently generate …
p63: a crucial player in epithelial stemness regulation | Oncogene
2023年10月17日 · In this review, we provide an overview of the role of p63 in epithelial stemness regulation, including self-renewal, differentiation, proliferation, and senescence. We describe …
p63: A Master Regulator at the Crossroads Between Development ...
The p63 protein is a master regulatory transcription factor that plays crucial roles in cell differentiation, adult tissue homeostasis, and chromatin remodeling, and its dysregulation is …
p63 Is Essential for the Proliferative Potential of Stem Cells in ...
Here we analyze p63, a gene whose deletion in mice results in the catastrophic loss of all stratified epithelia. We demonstrate that p63 is strongly expressed in epithelial cells with high …
Autologous transplantation of P63 - Cell Press
2024年11月19日 · Yan et al. demonstrate that autologous P63+ progenitor cell transplantation enhances lung gas exchange function, quality of life, CT imaging outcomes, and …
Autologous P63+ lung progenitor cell transplantation in …
2024年12月13日 · In a very recent report of a controlled phase 1 clinical trial, autologous P63+ progenitor cell transplantation was performed to treat 17 patients with chronic pulmonary …
Peer review in Autologous P63+ lung progenitor cell ... - eLife
2025年3月4日 · For instance, p63+ stem cells from the nasal and tracheal mucosa appear committed to upper airway epithelia marked by 90% ciliated cells and 10% goblet cells (Kumar …
p63-related signaling at a glance - PMC - PubMed Central (PMC)
p63 (also known as TP63) is a transcription factor of the p53 family, along with p73. Multiple isoforms of p63 have been discovered and these have diverse functions encompassing a wide …
p63 expression in human tumors and normal tissues: a tissue …
In diagnostic pathology, the consistently high expression of p63 in specific cell and tissue types is exploited for diagnostic purposes. For example, p63 immunohistochemistry (IHC) is commonly …