2024年12月25日 · TP63 (Tumor Protein P63) is a Protein Coding gene. Diseases associated with TP63 include Adult Syndrome and Limb-Mammary Syndrome. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Gene expression (Transcription).

Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and differentiation. In a recent study, researchers used EEC-patient-derived skin keratinocytes carrying heterozygous p63 DNA-binding domain mutations as the cellular model to characterize the global gene regulatory alteration.

The TP63 gene provides instructions for making a protein called tumor protein p63 (also known simply as p63). The p63 protein functions as a transcription factor, which means it attaches (binds) to certain regions of DNA and controls the activity of particular genes.

Tumor protein 63 (p63) is a transcription factor of the p53 gene family encoded by the TP63 gene located at chromosome 3q28. p63 regulates the activity of a multitude of genes involved in growth and development of the ectoderm and derived structures and tissues, such as basal layer keratins and cell cycle control genes .

The p63 protein is a master regulatory transcription factor that plays crucial roles in cell differentiation, adult tissue homeostasis, and chromatin remodeling, and its dysregulation is associated with genetic disorders, physiological and premature aging, and cancer.

The p63 gene is regulated by GRHL2 through reciprocal feedback and determines the epithelial phenotype in human keratinocytes. TAZ negatively regulate transcription of DeltaNp63 through TEAD1,2,3 and 4 transcription factors. P63 and HOXB13 is helpful in resolving the diagnosis.

2025年2月8日 · This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain.

2011年7月15日 · The integrin alpha(v)beta(3–5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast...

The p63 gene encodes multiple protein isoforms that serve a vast array of functions encompassing nearly all aspects of cellular signaling. Genetic studies in mice have shed much light on the roles of TAp63 versus ΔNp63 isoforms and their various functions.

肿瘤蛋白 p63： 该基因编码 p53 转录因子家族的成员。 p53 家族蛋白的功能域包括一个 N 端反式激活域、一个中心 DNA 结合域和一个寡聚化域。 该基因的选择性剪接和替代启动子的使用导致编码不同亚型的多个转录变体，这些亚型的功能特性各不相同。