2 天之前 · Immunohistochemistry demonstrated a strong nuclear expression of p63 in the basal cells of the hyperplastic glands. These features correlate with benign prostatic hyperplasia. Which of the statements below regarding p63 is true? B. Loss of p63 expression correlates with poor prognosis in urothelial carcinoma.

2021年1月25日 · In diagnostic pathology, the consistently high expression of p63 in specific cell and tissue types is exploited for diagnostic purposes. For example, p63 immunohistochemistry (IHC) is commonly used to mark cell types with critical impact on cancer diagnosis such as basal cells in prostatic and breast glands.

2023年11月27日 · This article reviews the applications of p63 IHC in diagnostic breast pathology and outlines, in more detail, a practical approach to the diagnosis and characterization of selected breast lesions through the identification of normal and abnormal p63 protein expression.

2023年11月14日 · Immunohistochemistry (IHC) is a test pathologists perform to see p63-producing cells in a tissue sample. When combined with other immunohistochemical markers, this test allows pathologists to determine if the cells they are seeing under the microscope come from one of the organ systems that normally produces this protein.

Staining for p63 can enhance detection of epithelial differentiation, but its usefulness is offset by expression in various soft tissue proliferations. Staining for p40—a squamous-specific isoform of p63—could potentially improve diagnostic accuracy.

TP63, a member of the TP53 gene family, is a nuclear marker of myoepithelial cells. Antibody against p63 is frequently used to aid in the diagnosis of prostate carcinoma, as well as in the identification of myoepithelial cells in other tissues including the breast. p63 is …

2010年8月17日 · Our goals in this study were (1) to further confirm our microarray data, (2) to analize the value of P63 immunohistochemistry (IHC) in reducing the number of large cell carcinoma (LCC) diagnoses in surgical specimens, and (3) to investigate the potential of P63 IHC to minimize the proportion of "carcinoma NOS (not otherwise specified)" in a ...

2024年10月15日 · P63是免疫组化检查中的一个关键指标，它作为肌上皮细胞中一种具有高度特异性和敏感性的肿瘤标志物，在细胞的增殖、分化和凋亡等生物学过程中发挥着重要作用，其阳性表达与肿瘤细胞的生物学特征密切相关。 P63是一种核转录因子，属于抑癌基因家族成员。 在免疫组化染色过程中，P63常被用作标记物，帮助确定肿瘤细胞和肿瘤组织中的肌上皮和上皮细胞等成分。 当免疫组化检查结果显示P63阳性时，通常表示样本中存在P63蛋白，可能包含肌上皮细胞 …

Immunohistochemistry (IHC) The p63 protein is a member of the p53 family of tumor-suppressor proteins. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. p63 is negative in malignant tumors of the prostate. Striated muscle staining may be observed with p63.

2011年5月27日 · TP63, a member of the TP53 gene family, is a nuclear marker of myoepithelial cells. Antibody against p63 is frequently used to aid in the diagnosis of prostate carcinoma, as well as in the...