2024年2月14日 · Adult lung resident stem/progenitor cells, including P63 + progenitor cells, have demonstrated the capacity for regeneration of lung epithelium in preclinical models. Here, we …

2024年11月7日 · Our study identifies secretory-cell-derived p63 + progenitors as contributors to alveolar repair, suggesting a potential therapeutic avenue for lung regeneration following …

2024年9月5日 · 为了解析肺上皮细胞参与修复的动态过程，研究人员利用博莱霉素诱导的肺泡上皮损伤模型，意外发现气道上皮基底干细胞的标志基因 p63 在损伤后的肺泡区域显著表达。 为 …

2024年2月14日 · P63 + lung progenitor cells can be easily isolated, expanded, and transplanted for lung regeneration. This study demonstrated the feasibility and safety of bronchoscopic …

2025年2月3日 · Here we show that in murine and monkey models, the KRT5 + P63 + progenitor cells in airway basal layer can enter the alveolar area post fibrotic injury. Aided with an …

2024年12月13日 · After 3-5 weeks of cell expansion, up to 100 million P63+ lung progenitor cells were produced and transplanted into the lungs of IPF patients via bronchoscopy. The safety …

2024年11月19日 · In order to study whether the autologous P63 + progenitor cells could repair the bronchiectasis lung, we conducted a single-blind, randomized, controlled clinical trial …

Ref. 14). In contrast, p63+ stem cells from distal lung differentiate to epithelia replete with Club, AT2, and AT1 markers. The spectrum of p63+ stem cells in the normal bronchi of any …

2024年11月19日 · Non-cystic fibrosis bronchiectasis is a progressive respiratory disease with limited treatment options, prompting the exploration of regenerative therapies. This study …

2024年11月19日 · Yan et al. demonstrate that autologous P63+ progenitor cell transplantation enhances lung gas exchange function, quality of life, CT imaging outcomes, and …