NF-κB p65 (D14E12) XP - Cell Signaling Technology (CST)
NF-κB p65 Antibody (D14E12) XP® Rabbit mAb #8242: A high-sensitivity antibody for diverse applications like WB, IP, IHC, IF. Learn more here. Render Target: SSR
Molecular network of ChIP-Seq-based NF-κB p65 target genes …
KEGG, PANTHER, and Ingenuity Pathways Analysis (IPA) revealed that the NF-κB p65 target gene network is linked to regulation of immune functions and oncogenesis, including B cell receptor signaling, T cell activation pathway, Toll-like receptor signaling, and apoptosis signaling, and molecular mechanisms of cancers.
CHIP promotes the activation of NF-κB signaling through ... - Nature
2021年9月17日 · Overexpression of CHIP promoted the degradation of endogenous IκBα in HEK293T and SHSY5Y cells, increased the nuclear translocation of p65, enhanced the transcription of IL-1β and TNFα ...
Molecular network of ChIP-Seq-based NF-κB p65 target genes …
2014年1月1日 · We identified the comprehensive set of 918 NF-κB p65 binding sites on protein-coding genes from chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) dataset of TNFα-stimulated human B lymphoblastoid cells. The molecular network was studied by a battery of pathway analysis tools of bioinformatics.
Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer …
2021年8月31日 · Here, we find that nuclear factor-kB (NF-κB) p65 is a new substrate of FBXW2. FBXW2 directly binds to p65, leading to its ubiquitination and degradation. Interestingly, p300 acetylation of...
Unconventional p65/p52 NF-κB module regulates key tumor ...
2024年11月15日 · We demonstrated by ChIP-qPCR that p65/p52 enrichment on HSPG2 and CSF-1 regulatory regions is strictly dependent on macrophage polarization and tumor environment. Our data provide novel mechanisms of transcriptional regulation in TAMs, orchestrated by the varied and dynamic nature of NF-κB combinations, which needs to be considered when ...
phosphorylation of p65 by multiple kinases activates NF-κB, allowing it to transport to the nucleus and cause the transcriptional activation of many of its target genes containing κB sites (consensus sequence: gggRNNYYcc, R=purine Y=pyrimidine), such as PUMA, IL-6, and TNF.
Nrf2 suppresses macrophage inflammatory response by blocking ...
2016年5月23日 · Microarray and Nrf2 Chromatin immunoprecipitation (ChIP) -seq analyses revealed that Nrf2 binds to the proximity of the proinflammatory cytokine genes, including IL6 and IL1b, and inhibits...
NF-κB p65 antibody (10745-1-AP) | Proteintech - ptglab
10745-1-AP targets NF-κB p65 in WB, IHC, IF/ICC, IP, CoIP, ChIP, ELISA applications and shows reactivity with human, mouse, rat samples.
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ChIPAb+ NFκB p65 (RelA) - ChIP经验证的抗体和引物组
NFκB p65（RelA）和阴性对照以可扩展的“每个ChIP”反应大小提供，可用于功能上验证NFκB p65（RelA）相关染色质的沉淀。 转录因子NFkappaB（Nuclear Factor kappa B）可参与许多重要细胞和生理过程的表达和调控，例如生长、发育、凋亡、免疫和炎症反应以及各种病毒启动 ...