2024年9月30日 · Simultaneous silencing of TXNIP prevents H 2 O 2-stimulated p65 phosphorylation. This suggests that the NF-κB pathway is also activated after oxidative stress …

2017年6月1日 · The acetylation of p65 by CBP was strongly reduced due to HDAC1, HDAC3 and TXNIP. The C247 region of TXNIP strongly interacted with HDAC1 and HDAC3. The …

2020年7月28日 · Mechanistically, NF-κB p65 downregulated the miR-183 expression via the upregulation of HDAC2 and further induced inflammatory response by activating the TXNIP …

nf-κb p65是nf-κb家族成员之一，nf-κb是一种多效性转录因子，几乎存在于所有细胞类型中，并参与许多生物学过程，例如炎症，免疫，分化，细胞生长，肿瘤发生和凋亡。nf-κb受翻译后修 …

2013年10月3日 · In this previous study, we observed that TXNIP inhibited CBP (CREB-binding protein)-induced NF-κB activation and p65 acetylation. Moreover, TXNIP could bind to HDAC1 …

2022年10月31日 · In this study, we investigated the role of thioredoxin interacting protein (TXNIP) in acute pancreatitis when induced by high doses of arginine. We found that pancreatic …

Macrophage TXNIP deficiency enhances CYLD activity and activates the NRF2-OASL1 signalling, controlling IR stress-induced liver injury. The target gene OASL1 regulated by NRF2 is crucial …

2024年9月10日 · We found that H 2 O 2 treatment induced oxidative stress injury in HEI-OC1 cells, as evidenced by decreased cell viability and increased total intracellular and …

1 天前 · TXM-CB13 blockade reduced NLRP3 activation by modulating NF-κB-related proteins (TLR4, MyD88, p-p65/p65, and p-IKB-α/IKB-α) (Fig. 5). These results suggest that blocking …

2022年11月1日 · Calycosin's powerful action against STZ-induced DM was revealed not only through the regulation of renal functions in DN, but also through other multiple valuable actions …