
Silencing of TXNIP attenuates oxidative stress injury in HEI-OC1 …
2024年9月30日 · Simultaneous silencing of TXNIP prevents H 2 O 2-stimulated p65 phosphorylation. This suggests that the NF-κB pathway is also activated after oxidative stress …
Macrophage migration inhibitory factor interacts with …
2017年6月1日 · The acetylation of p65 by CBP was strongly reduced due to HDAC1, HDAC3 and TXNIP. The C247 region of TXNIP strongly interacted with HDAC1 and HDAC3. The …
NF-κB p65-dependent transcriptional regulation of histone …
2020年7月28日 · Mechanistically, NF-κB p65 downregulated the miR-183 expression via the upregulation of HDAC2 and further induced inflammatory response by activating the TXNIP …
靶点解惑Plus | NLRP3/NF-Kb P65/TLR4/IL-β信号通路详解!6个真 …
nf-κb p65是nf-κb家族成员之一,nf-κb是一种多效性转录因子,几乎存在于所有细胞类型中,并参与许多生物学过程,例如炎症,免疫,分化,细胞生长,肿瘤发生和凋亡。nf-κb受翻译后修 …
TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction …
2013年10月3日 · In this previous study, we observed that TXNIP inhibited CBP (CREB-binding protein)-induced NF-κB activation and p65 acetylation. Moreover, TXNIP could bind to HDAC1 …
Thioredoxin-interacting protein deficiency protects against severe ...
2022年10月31日 · In this study, we investigated the role of thioredoxin interacting protein (TXNIP) in acute pancreatitis when induced by high doses of arginine. We found that pancreatic …
Novel role of macrophage TXNIP-mediated CYLD–NRF2–OASL1 …
Macrophage TXNIP deficiency enhances CYLD activity and activates the NRF2-OASL1 signalling, controlling IR stress-induced liver injury. The target gene OASL1 regulated by NRF2 is crucial …
Silencing of TXNIP attenuates oxidative stress injury in HEI-OC1 …
2024年9月10日 · We found that H 2 O 2 treatment induced oxidative stress injury in HEI-OC1 cells, as evidenced by decreased cell viability and increased total intracellular and …
TXM-CB13 Improves the Intestinal Mucosal Barrier and ... - Springer
1 天前 · TXM-CB13 blockade reduced NLRP3 activation by modulating NF-κB-related proteins (TLR4, MyD88, p-p65/p65, and p-IKB-α/IKB-α) (Fig. 5). These results suggest that blocking …
Calycosin modulates NLRP3 and TXNIP-mediated pyroptotic
2022年11月1日 · Calycosin's powerful action against STZ-induced DM was revealed not only through the regulation of renal functions in DN, but also through other multiple valuable actions …