2024年9月30日 · Simultaneous silencing of TXNIP prevents H 2 O 2-stimulated p65 phosphorylation. This suggests that the NF-κB pathway is also activated after oxidative stress in HEI-OC1 cells, and that the inhibition of TXNIP overexpression prevents the activation of this pathway and exerts antioxidant and anti-inflammatory effects.

2017年6月1日 · The acetylation of p65 by CBP was strongly reduced due to HDAC1, HDAC3 and TXNIP. The C247 region of TXNIP strongly interacted with HDAC1 and HDAC3. The combination of TXNIP and HDAC1 or HDAC3 synergistically suppresses NF-κB activity.

2020年7月28日 · Mechanistically, NF-κB p65 downregulated the miR-183 expression via the upregulation of HDAC2 and further induced inflammatory response by activating the TXNIP-NLRP3 inflammasome axis, thus aggravating the neuropathic pain in CCI rats and microglial cells.

nf-κb p65是nf-κb家族成员之一，nf-κb是一种多效性转录因子，几乎存在于所有细胞类型中，并参与许多生物学过程，例如炎症，免疫，分化，细胞生长，肿瘤发生和凋亡。nf-κb受翻译后修饰和亚细胞区室化的各种机制以及与其他辅因子或共抑制因子的相互作用的 ...

2013年10月3日 · In this previous study, we observed that TXNIP inhibited CBP (CREB-binding protein)-induced NF-κB activation and p65 acetylation. Moreover, TXNIP could bind to HDAC1 and HDAC3 and co-localize with HDAC1 and HDAC3, and NF-κB activation by CBP was synergistically decreased by HDAC1, HDAC3, and TXNIP.

2022年10月31日 · In this study, we investigated the role of thioredoxin interacting protein (TXNIP) in acute pancreatitis when induced by high doses of arginine. We found that pancreatic damage and the...

Macrophage TXNIP deficiency enhances CYLD activity and activates the NRF2-OASL1 signalling, controlling IR stress-induced liver injury. The target gene OASL1 regulated by NRF2 is crucial for modulating STING-mediated TBK1 activation and Apaf1/cytochrome c/caspase-9-triggered apoptotic/necroptotic cell death pathway.

2024年9月10日 · We found that H 2 O 2 treatment induced oxidative stress injury in HEI-OC1 cells, as evidenced by decreased cell viability and increased total intracellular and mitochondrial ROS levels (p < 0.05). TXNIP expression was elevated, and NLRP3 and NF …

1 天前 · TXM-CB13 blockade reduced NLRP3 activation by modulating NF-κB-related proteins (TLR4, MyD88, p-p65/p65, and p-IKB-α/IKB-α) (Fig. 5). These results suggest that blocking the NF-κB signaling pathway with TXM-CB13 protects against colitis. The second signaling pathway involves the ROS/TXNIP/NLRP3 inflammasome pathway.

2022年11月1日 · Calycosin's powerful action against STZ-induced DM was revealed not only through the regulation of renal functions in DN, but also through other multiple valuable actions including, down-regulating TXNIP gene expression resulting in oxidative stress suppression through enhancing Nrf2 anti-oxidative pathway and inhibiting inflammatory response ...