2 天之前 · Here we present a modular platform to design programmable mRNA therapeutics, Epigenomic Controllers (EC), that control gene expression through directed epigenetic change. ... H3K27ac- and P65-ChIP ...

p65-RelA是哺乳动物NF-κB家族的成员，该家族由5个亚基组成：p50-NF-κB1，p52-NF-κB2，c-Rel，p65-RelA和RelB。 NF-κB的转录活性受翻译后修饰（例如p65-NF-κB亚基的磷酸化和乙酰化）的完全激活所调节。

1 天前 · In this study, ANRIL was found to downregulate p-p65 and p-IκBα, while simultaneously inhibiting the nuclear translocation of p-p65, thus suppressing the activation of the NF-κB signaling pathway. However, ANRIL could not bind with either p65 protein or mRNA, suggesting that ANRIL might inhibit the NF-κB signaling pathway indirectly.

1 天前 · Endothelial TDP-43 loss coincides with increased nuclear p65/NF-κB activity and reduced Wnt/β-catenin. ... Meanwhile, the mRNA-derived cDNA, attached to SPRI beads, was processed for gene ...

2025年3月4日 · Next, we measured mRNA and protein levels of GCN5 in the brains of LPS-treated mice at different times and with different LPS concentrations. ... or CPTH2 [(B); 3 mg/kg, ip] for 3 consecutive days before LPS (5 mg/kg) challenge. Levels of acetylated (ac-p65) and unacetylated (p65) NF-κB p65 protein in the whole brain, cortex, and hippocampus ...

Hence, the NF-κB p65 signaling pathway has been a pivotal point for intense drug discovery and development. This review begins with an overview of p65-mediated signaling followed by discussion of strategies that directly target NF-κB p65 in the context of chronic inflammation. Keywords: NF-κB, inflammation, therapy.

Here we show that in mice and humans there is a spliced variant of p65, named p65 iso5, which binds the corticosteroid hormone dexamethasone amplifying the effect of the glucocorticoid receptor and is expressed in the liver of patients with hepatic cirrhosis and hepatocellular carcinoma (HCC).

2013年1月4日 · We found that the p65 Ser-311 mutant was more efficiently recruiting p-RNAP II to promoters of genes in group I than the other mutants, which could account for the high mRNA induction levels despite lower p65 binding. Other than that, p-RNAP II binding profiles matched the ones for p65 in groups I and III; however, in group II this was not the ...

2023年3月21日 · We found that DDX58 acts as an RNA-binding protein, stabilizes p65 mRNA, and promotes its expression, which in turn activates the release of proinflammatory factors and arrests the growth of Sertoli cells.

Vav1 controls downstream p65 phosphorylation and NF-κB activation. Synergistic signalling is defective in X-linked lymphoproliferative disease (XLP1) NK cells entailing 2B4 dysfunction and required for p65 phosphorylation by PI3K-Akt signal, suggesting stepwise signalling checkpoint for NF-κB activation.