Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. [5][6] It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. [7] .

Recent studies have suggested that plasma p70S6K is a reliable index for the monitoring of patient response to mTOR inhibitors. Therefore, a better understanding of p70S6K and its role in various pathological conditions could enable the development of strategies to aid diagnosis, prognosis and treatment schedules.

In this review, we will discuss current findings of p70 S6K in the control of actin cytoskeleton dynamics. In addition, the potential role of p70 S6K in spermatogenesis and testicular function will be highlighted. Keywords: actin, cancer, Cdc42, germ cell, p70 S6 kinase, Rac1, spermatogenesis, testis.

2008年7月24日 · Our results show for the first time the genome-wide transcriptional consequences of PI3K/mTOR pathway and RPS6KB1 inhibitions in breast cancer, suggesting novel downstream targets for PI3K/mTOR pathway and p70S6 kinase.

P70S6 Kinase, also known as S6K1, is a serine/threonine kinase that plays a crucial role in controlling translation by phosphorylating key proteins involved in protein synthesis. It is a downstream effector of mTORC1 and ERK signaling pathways, influencing synaptic plasticity and cell proliferation in the context of neuroscience.

2001年8月7日 · Here, we purified membrane-based 70-kDa ribosomal protein S6 kinase (p70S6K) as a BAD S136-specific kinase. Rapamycin, which blocks mitochondrial-based p70S6K activity, inhibits IGF-1-induced BAD S136 phosphorylation and cell survival. The p70S6K-deficient cells support the importance of IGF-1-induced BAD S136 phosphorylation by this kinase.

p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1,2). p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs (1).