2024年12月26日 · In this review, the postbiotic proteins p40, p75, and HM0539 derived from lactobacilli and their functional effects are systematically summarized. The p40 protein, in particular, has been shown to support gut barrier activity and reduce inflammation, potentially through mechanisms involving epidermal growth factor receptor-dependent signaling.

2021年8月31日 · p75 神经营养素受体 (p75 ntr) 在细胞死亡、存活和分化的分子联系中发挥作用。 除了在神经退行性疾病和神经系统损伤中起作用外，最近的研究还揭示 ...

2009年4月4日 · In 2003 we identified LEDGF/p75 5 as the major cellular interaction partner of HIV ... , 270 n m; •, 900 n m) and different concentrations of MBP-JPO2 as indicated on the x axis. The experiment was done in triplicate. Data represent the average values ± S.D. for the three measurements. B, non-tagged LEDGF/p75 competes for the ...

2024年12月26日 · The p40 protein has been shown to support gut barrier activity and reduce inflammation, potentially through mechanisms involving epidermal growth factor receptor-dependent signaling, and p40 and p75 proteins exhibit protective effects on intestinal epithelial tight junctions, suggesting their therapeutic potential in preventing intestinal damage and diseases such as colitis. It is known that ...

Additionally, p40 and p75 proteins exhibit protective effects on intestinal epithelial tight junctions, suggesting their therapeutic potential in preventing intestinal damage and diseases such as colitis. ... Modulation of the TLR4/Myd88/NF-kB axis signaling pathway: Lipopolysaccharide-stimulated RAW 264.7 macrophages and, in dextran sulfate ...

2021年7月7日 · 30 mesenchymal NGF-p75 axis which operates to induce cellular migration. Together, our data 31 suggest a direct effect of myeloid-derived NGF on progenitor cells, ... (5). p75 expression has been correlated to cell migration and invasion in the fields of 48 developmental and cancer biology. For example, Schwann cell migration from the dorsal root

2023年8月11日 · Taken together, these results implicate the GR–LEDGF/p75 axis in PCa cell resistance to taxane therapy and are consistent with growing evidence demonstrating a role for these proteins in therapy resistance in various human cancer types. The GR-mediated upregulation of LEDGF/p75 in enzalutamide-resistant cells needs to be further evaluated in ...

2025年1月17日 · Y axis of the plot representing prion-like regions and regions of background amino acid composition (0). Posttranslational modification sites in SPT5-PRD. ... Loss of IBD in LEDGF/p75 led to a profound increase in phosphorylation levels of SPT5 at PRD and also a substantial increase in nascent RNA synthesis ...

2017年10月10日 · Isl1-Cre +/−; p75 F/F mice lose 20% of DRG neurons. p75 immunofluorescence staining of DRG sections from E10.5, E12.5 and adult p75 F/F and Isl1-Cre +/−; p75 F/F mice is shown in A-F. As shown in panel D, p75 immunoreactivity in DRG sensory neurons is not reduced at E10.5 in Isl1-Cre +/−; p75 F/F mice. However, the number of p75 ...

2024年12月26日 · Probiotic Bacterium-Derived p40, p75, and HM0539 Proteins as Novel Postbiotics and Gut-Associated Immune System (GAIS) Modulation: Postbiotic-Gut-Health Axis December 2024 Microorganisms 13(1):23