Project 77 (formerly Project 75 Alpha) is an Indian Navy acquisition programme to procure nuclear-powered attack submarines. [2] The Government of India, through the Cabinet Committee on Security (CCS), approved the construction of six of these submarines in February 2015. [3]

2020年9月11日 · Gene network analyses showed multiple known and new targets in the p75NTR gene network. This study provides a comprehensive analysis and investigation into the current knowledge of p75NTR signaling...

2024年5月17日 · Modulation of p75 NTR with the first-in-class small molecule LM11A-31 mitigates amyloid-induced and pathological tau-induced synaptic loss in preclinical models.

We have investigated the role of p55 and p75 tumor necrosis factor receptors 1 and 2 (TNFR1 and TNFR2, respectively) in TNF-induced alteration of endothelial permeability in vitro and in vivo. Stimulation of TNFR1 with an agonist antibody or a receptor …

Recently, the p75 neurotrophin receptor (p75 NTR) has emerged as a potential target for pharmacological control of neurotrophin activity, supported in part by studies demonstrating 1) regulation of neural plasticity in the mature nervous system, 2) promotion of adult neurogenesis and 3) increased expression in neurons, macrophages, microglia ...

2013年12月16日 · In this study, we have investigated the mechanism of sAPPα-mediated neurotrophic effects. sAPPα and sAPPβ interact with p75 neurotrophin receptor (p75 NTR), and sAPPα promotes neurite outgrowth. First, we investigated whether APP fragments interact with p75 NTR, because full-length APP and Aβ have been shown to interact with p75 NTR in vitro.

2005年4月15日 · The p75 neurotrophin receptor (p75(NTR)), a member of the tumor necrosis factor superfamily of receptors, undergoes multiple proteolytic cleavage events. These events are initiated by an alpha-secretase-mediated release of the extracellular domain followed by a gamma-secretase-mediated intramembrane …

In glial cells and some neurons that express p75 but not TrkA, p75 causes cell death in response to nerve growth factor (NGF) binding. In sensory neurons and PC12 cells, p75 appears to signal constitutively. In cholinergic forebrain neurons, p75 expression leads to atrophy and downregulation of cholinergic markers, rather than cell death.

2017年10月20日 · 感觉神经元控制大脑识别疼痛、触觉、运动和空间定位。Salk研究所的研究表明p75蛋白在疼痛神经回路中起重要作用，结论将影响伤性脊髓损伤等疾病治疗。 “p75蛋白是个爱管闲事的家伙，它参与各种不同信号通路，”Kuo-Fen Lee教授说。

2015年4月28日 · Our data demonstrate that p75ECD is a physiologically neuroprotective molecule against Aβ toxicity and would be a novel therapeutic target and biomarker for AD.