NAR | 揭秘eIF4F和eIF4B如何助力闭环结构完成翻译终止任务
2 天之前 · 研究表明，PABP增强eIF4G1、eIF4A和eIF4B在翻译终止中的活性，尤其是在poly(A)尾存在时。 PABP通过直接与eIF4G1和eIF4B相互作用来增强活性，而eIF4A则可能通过与其他 …
Cell | 杜克大学董欣年团队研究揭示植物免疫中新的翻译启动机制！ …
聚（A）结合蛋白（PABP）促进了43S PIC对5′帽的招募，PABP通过与eIF4F复合物中的eIF4G相互作用从mRNA的3′聚（A）尾部绕回来。 在对胁迫的反应中，一般的翻译启动往往通过胁迫 …
Single-molecule visualization of mRNA circularization during ...
2023年1月31日 · Most mRNAs are circularized via the eIF4E–eIF4G–PABP interaction, which stabilizes mRNAs and enhances translation by recycling ribosomes. However, studies using …
Plant growth and fertility requires functional interactions between ...
2018年1月30日 · Despite their divergence, eIF4G and eIFiso4G interact with eIF4A, eIF4B, and eIF4E isoforms needed for binding an mRNA. eIF4G and eIFiso4G also interact with the …
Interaction of polyadenylate-binding protein with the eIF4G ... - Nature
1998年4月2日 · Here, we describe a new human PABP-interacting protein, PAIP-1, whose sequence is similar to the central portion of eIF4G and which interacts with eIF4A. …
Poly(A)-Binding Protein-Interacting Protein 1 Binds to Eukaryotic ...
Poly(A)-binding protein (PABP) stimulates translation initiation by binding simultaneously to the mRNA poly(A) tail and eukaryotic translation initiation factor 4G (eIF4G). PABP activity is …
Dynamic interaction of poly(A)-binding protein with the ribosome …
2018年11月28日 · Here, we show that PABP interacts with the 40S and 60S ribosomal subunits dynamically via RRM2-3 or RRM3-4. Using a reconstituted protein expression system, we …
eIF4G, eIFiso4G, and eIF4B Bind the Poly(A)-binding Protein …
The poly(A)-binding protein (PABP), a protein that contains four conserved RNA recognition motifs (RRM1–4) and a C-terminal domain, is expressed throughout the eukaryotic kingdom …
Eukaryotic initiation factors eIF4F and eIF4B promote translation ...
5 天之前 · The eRF1–eRF3–GTP complex then associates with either the same or a neighboring PABP molecule on the poly (A) tail. As the elongating ribosome encounters the stop codon …
Competitive and noncompetitive binding of eIF4B, eIF4A, and the …
2010年9月28日 · Eukaryotic translation initiation factor 4G (eIF4G) functions to organize the assembly of initiation factors required for the recruitment of a 40S ribosomal subunit to an …