2024年3月25日 · By overlapping DEGs positively correlated with HIV-1/PAH and genes shared from WGCNA-related modules, we ultimately identified hub genes through a Venn diagram.

2024年2月17日 · 肺动脉高压（pulmonary arterial hypertension，PAH）是一类复杂的病理生理综合征，特征为血管重构和管腔狭窄，导致肺血管阻力和肺动脉压力逐渐升高，最终可能引发右心衰竭甚至死亡，因此被视为一种高致死率的心血管疾病[1-2]。 目前，PAH的治疗主要集中在三大通路：内皮素通路、前列环素通路和一氧化氮（NO）通路[3-4]。 虽然这些治疗方法可以缓解患者的临床症状并改善血流动力学，但未能有效抑制肺血管重构，无法从根本上阻止PAH的进展，进而 …

2024年8月3日 · Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disease. However, there is a paucity of studies that reflect the available biomarkers from separate gene expression profiles in PAH. The GSE131793 and GSE113439 datasets were combined for subsequent analyses, and batch effects were removed.

肺动脉高压（pulmonary hypertension， PH）是指由多种异源性疾病（病因）和不同发病机制所致肺血管结构或功能改变，引起肺血管阻力和肺动脉压力升高的临床和病理生理综合征，继而发展成右心衰竭甚至死亡。 近年来PH领域诊断及治疗策略不断更新，国内外在不同领域发表了PH相关指南和专家共识。 为更好指导我国医师的临床实践，中华医学会呼吸病学分会肺栓塞与肺血管病学组、中国医师协会呼吸医师分会肺栓塞与肺血管病工作委员会基于当前的循证医学证据，制订了 …

2024年10月25日 · Pulmonary arterial hypertension (PAH) is a life-threatening disease with a poor prognosis, and metabolic abnormalities play a critical role in its...

肺动脉高压 ( PAH) 指肺动脉压力异常升高的一种血流动力学和病理生理状态，是一种致命性心肺疾病，最新流行病学数据显示特发性和遗传性 PAH 发病率为每百万居民 5 例，患病率为每百万居民 25 例，并且逐年增加趋势…

2025年1月20日 · Down-regulation of electron transport from cytochrome c to oxygen in mitochondrial ETC and disruption of the citric acid cycle homeostasis may contribute to PAH pathogenesis. 3-phenyllactic acid emerges as a potential novel diagnostic biomarker for PAH. These findings offer insights for developing novel PAH therapies and diagnostics.

2023年1月4日 · Identifying and understanding different molecular surrogates for disease severity and RV maladaptation is important for improving PAH outcomes and optimizing patient care. We used a systems biology approach to identify distinct metabolomic profiles associated with RV dilation, mortality, and metrics of disease severity in PAH.

2023年8月21日 · Ferroptosis plays a critical role in pulmonary arterial hypertension (PAH)-induced right ventricular (RV) dysfunction, but key genes remain largely unclear. We here identified HMOX1 as an essential ferroptosis-related differentially expressed gene in PAH by bioinformatic analysis using FerrDb, GSE119754, and GSE3675 datasets, respectively.

2024年12月25日 · PAH (Phenylalanine Hydroxylase) is a Protein Coding gene. Diseases associated with PAH include Phenylketonuria and Hyperphenylalaninemia. Among its related pathways are Biogenic amine synthesis and tyrosine degradation.