The present review focuses on recent studies showing that PARs are critically involved in itch and sensitization of itch. PARs are expressed by diverse cell types including primary sensory neurons, keratinocytes, and immune cells and are activated by proteases that expose a tethered ligand.

Finally, several studies suggest that activation of PAR-2 can also elicit itch, either directly by activation of the receptor on sensory nerve fibers innervating the skin, or indirectly by activating keratinocytes or immune cells (e.g., mast cells), and thereby induce a cascade leading to release of pruritogens that in turn activate sensory ...

2006年7月1日 · In contrast to the separated neuronal pathways, the results have revealed that a broad overlap exists between pain and itch processing in terms of mediators, mechanisms and even therapeutic...

2023年11月22日 · Pruriceptors are activated by V8 protease through proteinase-activated receptor 1 (PAR1). Targeting V8 or PAR1 abrogates itch and barrier damage, leading to improved skin pathology. Our findings uncover a role for bacterial proteases in itch and PAR1 as a candidate for therapeutic development.

2023年11月22日 · Protease-activated receptors (PARs) belong to the G protein-coupled receptor family and are activated upon protease cleavage of the extracellular domain. Importantly, PARs are expressed by pruriceptors that mediate itch, and the authors, using a luminescence-based PAR cleavage assay, confirm that human PAR1 specifically cleaves V8 protease.

The present review focuses on recent studies showing that PARs are critically involved in itch and sensitization of itch. PARs are expressed by diverse cell types including primary sensory neurons, keratinocytes, and immune cells and are activated by proteases that expose a tethered ligand.

The present review focuses on recent studies showing that PARs are critically involved in itch and sensiti-zation of itch. PARs are expressed by diverse cell types including primary sensory neurons, keratinocytes, and immune cells and are activated by proteases that expose a …

2015年4月11日 · Protease-activated receptors (PARs) have been implicated in a variety of physiological functions, as well as somatosensation and particularly itch and pain....

2013年5月1日 · In this review, we provide new insights into distinct molecular mechanisms of itch, especially nonhistaminergic itch signaling, mediated by Mas-related G protein-coupled receptor (Mrgprs), protease-activated receptors (PARs), toll-like receptors (TLRs), oxidative stress, transient receptor potential cation channel subfamily V1/A1 (TRPV1/A1 ...

2023年12月8日 · Emerging evidence clearly implicates TRP channels, Mrgprs, and PARs in a variety of itch-inducing mechanisms relevant to diseases which produce chronic itch. Since these channels and receptors are peripherally expressed and can mediate both inflammation and itch, they represent promising targets for the development of antipruritic pharmaceuticals.