
Pax5: the guardian of B cell identity and function - Nature
2007年4月17日 · Conditional Pax5 inactivation in early and late B lymphocytes revealed an essential role for Pax5 in controlling the identity and function of B cells throughout B …
Pax5: a master regulator of B cell development and leukemogenesis
At B cell commitment, Pax5 restricts the developmental potential of lymphoid progenitors to the B cell pathway by repressing B-lineage-inappropriate genes, while it simultaneously promotes B …
PAX5 - Wikipedia
The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation.
PAX-5: A Valuable Immunohistochemical Marker in the Differential ...
PAX-5, a transcription factor expressed throughout B-cell maturation, is detected in most B-cell neoplasms including those that lack expression of mature B-cell markers, such as classical …
Pax5 regulates B cell immunity by promoting PI3K signaling
Here, we demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone (MZ), and germinal center …
Pax5: the guardian of B cell identity and function - PubMed
The transcription factor Pax5 is essential for commitment of lymphoid progenitors to the B lymphocyte lineage. Pax5 fulfils a dual role by repressing B lineage 'inappropriate' genes and …
A SIRT7-dependent acetylation switch regulates early B cell
2024年10月18日 · Here, we found that the NAD + -dependent enzyme SIRT7 coordinates B cell development through deacetylation of Pax5 at K198, which promotes Pax5 protein stability …
Pax5 regulates B cell immunity by promoting PI3K signaling via …
2021年7月23日 · Here, we demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone (MZ), and …
The B-cell identity factor Pax5 regulates distinct transcriptional ...
Pax5 controls the identity and development of B cells by repressing lineage-inappropriate genes and activating B-cell-specific genes. Here, we used genome-wide approaches to identify Pax5 …
The Pax-5 Gene: A Pluripotent Regulator of B-cell Differentiation …
2011年12月15日 · Given the pivotal importance of Pax-5–mediated processes in B-cell development, an aberrant regulation of Pax5 expression has consistently been associated with …