Paired box gene 9, also known as PAX9, is a protein which in humans is encoded by the PAX9 gene. [5][6] It is also found in other mammals. [7] This gene is a member of the paired box (PAX) family of transcription factors.

2024年12月25日 · PAX9 (Paired Box 9) is a Protein Coding gene. Diseases associated with PAX9 include Tooth Agenesis, Selective, 3 and Tooth Agenesis. Among its related pathways are Endoderm differentiation and Wnt / Hedgehog / Notch.

PAX9 functions as a tumor suppressor gene for cervical cancer via modulating cell proliferation and apoptosis. Patterns of molar agenesis associated with p.P20L and p.R77Q variants in PAX9. PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer. PAX7, PAX9 and RYK Expression in Cleft Affected Tissue.

2020年8月19日 · PAX9 functions as an RNA Polymerase II transcription factor to regulate the expression of proteins required for craniofacial and tooth development in humans. We now expand this function of PAX9 by demonstrating that PAX9 acts outside of the cell nucleolus to regulate the levels of proteins critical for building the small subunit of the ribosome.

2025年1月4日 · Title: Four Novel PAX9 Variants and the PAX9-Related Non-Syndromic Tooth Agenesis Patterns. PAX9 functions as a tumor suppressor gene for cervical cancer via modulating cell proliferation and apoptosis.

2021年8月1日 · Paired box 9 (PAX9) gene plays an important role during embryogenesis and organogenesis. Loss-of-function of PAX9 is associated with developmental abnormalities and short life span of the organism. PAX9 maintains squamous cell differentiation and its deficiency is linked with tumor initiation and malignant transformation.

该基因是转录因子配对盒 (PAX) 家族的成员。 该基因家族的成员通常包含一个配对盒域、一个八肽和一个配对型同源域。 这些基因在胎儿发育和癌症生长过程中发挥着关键作用。 缺乏该基因的小鼠表现出器官、肌肉组织和骨骼发育受损，包括牙齿缺失和异常发育，以及新生儿死亡。 人类基因的突变与选择性牙齿发育不全有关 3。 [RefSeq 提供，2015 年 9 月] This gene is a member of the paired box (PAX) family of transcription factors.

2020年8月19日 · PAX9 functions as an RNA Polymerase II transcription factor to regulate the expression of proteins required for craniofacial and tooth development in humans. We now expand this function of PAX9 by demonstrating that PAX9 acts outside of the cell nucleolus to regulate the levels of proteins critical for building the small subunit of the ribosome.

Paired box 9 (PAX9) is one of the best-known transcription factors involved in the development of human dentition. Mutations in PAX9 gene could, therefore, seriously influence the number, position and morphology of the teeth in an affected individual. To date, over 50 mutations in the gene have been …

Clinical resource with information about PAX9, Large-scale genotyping identifies 41 new loci associated with breast cancer risk., Tooth agenesis, selective, 3, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.