The influenza virus PB2 protein evades antiviral innate ... - Nature
2022年10月21日 · AIV PB2-mediated JAK1 degradation is critical for virus transcription and replication in vitro. To further identify the effect of JAK1 degradation by AIV PB2 on virus …
Prerequisites for the acquisition of mammalian pathogenicity by ...
2017年8月31日 · A prototypic PB2 gene of an H9N2 low-pathogenic AIV (LPAIV) strain, A/chicken/Korea/01310/2001 (H9N2) (01310), was not replicative and non-pathogenic (no …
Nature子刊｜扬州大学彭大新/陈素娟发现流感病毒PB2蛋白通过抑 …
2022年10月26日 · 甲型流感病毒 (IAV)聚合酶蛋白PB2已显示通过阻断干扰素 (IFN)的诱导来部分抑制宿主免疫反应。 然而，调节IFNs下游信号通路的IAV PB2蛋白没有很好的表征。 2022年10 …
Cellular hnRNPAB interacts with avian influenza viral protein PB2 …
2021年11月1日 · The PB2 protein of avian influenza virus (AIV) is essential for transcription and replication of virus genome. In this study, we reported that chicken heterogenous nuclear …
H5N1 avian influenza virus PB2 antagonizes duck IFN-β
2024年1月3日 · Here, we first found that the polymerase basic 2 (PB2) protein of H5N1 subtype AIV inhibited the type I IFN responses by targeting duck mitochondrial antiviral signaling …
PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 …
2016年1月19日 · The avian-origin H10N8, H7N9 and H9N2 viruses harboring PB2-588 V exhibited higher polymerase activity, more efficient replication in mammalian and avian cells …
PB2 residue 473 contributes to the mammalian virulence of H7N9 …
2024年2月29日 · In this study, we identified PB2 residue 473 as a new determinant of mouse virulence and mammalian adaptation of the viral polymerase of the H7N9 virus and its non …
Effect of the Interaction between Viral PB2 and Host SphK1 on H9N2 AIV ...
2022年7月21日 · The H9N2 avian influenza virus (AIV) is currently widespread worldwide, posing a severe threat to the poultry industry and public health. Reassortment is an important way for …
PB2蛋白E627K/V突变增强禽流感病毒 对哺乳动物适应性研究进展
2024年11月15日 · 文章分析了不同宿主来源的AIV中PB2蛋白第627位 氨基酸的多态性，总结了该位点适应哺乳动物的分子机制，强调了加强对禽源和哺乳动物源 AIV的分子标记监测对阻止未 …
Avian ANP32A incorporated in avian influenza A virions promotes ...
2024年1月31日 · The well-known mammalian adaptive mutations, such as PB2-E627K, enable AIV vPol to efficiently use mammalian ANP32 proteins when AIVs jump from avian hosts to …