2020年11月25日 · Here we report that neuropathic pain-like hypersensitivity induced by common peroneal nerve (CPN) ligation increases nociceptive stimulation-induced responses in glutamatergic LPBN neurons....

研究团队利用sni神经病理性疼痛模型，解析了脊髓投射神经元和接收脊髓信息输入的pbn神经元的功能，发现特异性凋亡靶标右侧pbn的神经元能显著缓解病理性疼痛诱发的痛觉过敏，而凋亡靶标左侧pbn的神经元不影响病理性疼痛的发展。

2025年2月19日 · In this study, we uncovered the lateralized function of the PBN in driving neuropathic pain, which depends on NK1R activation in the right-sided PBN. We also demonstrated that peripheral nerve injury induces short-term facilitation in the spino-parabrachial pathways targeting the right-sided PBN, regardless of the injury side.

2022年1月1日 · The parabrachial nucleus (PBN) is an important pontine nucleus that receives and transmits different sensory information, including pain. The PBN is comprised of distinct pain pathways that play an important role in the manifestation of emotional behavior, autonomic reaction, and learning due to pain, especially in animals.

2023年8月4日 · Together, our results indicate that the PBN→CeA pathway is a key modulator of pain-related behaviors that can increase reflexive-defensive and affective-motivational responses to somatosensory...

2019年10月16日 · The present review considers PBN as a “hub” for pain and aversion, with a focus on contributions to pain, bad taste and regulation of ingestive behaviors, and thermoregulatory challenge. The PBN is a cell grouping that surrounds the superior cerebellar peduncles in the dorsolateral pons.

2024年12月24日 · 研究者利用SNI神经病理性疼痛模型，解析了脊髓投射神经元和接收脊髓信息输入的PBN神经元的功能，发现特异性凋亡靶标右侧PBN的神经元能显著缓解病理性疼痛诱发的痛觉过敏，而凋亡靶标左侧PBN的神经元不影响病理性疼痛的发展。...

2024年8月14日 · The parabrachial nucleus (PBN) in the dorsal pons responds to bodily threats and transmits alarm signals to the forebrain. Parabrachial neuron activity is enhanced during chronic pain, and inactivation of PBN neurons in mice prevents the establishment of neuropathic, chronic pain symptoms.

The parabrachial nucleus (PBN) in the dorsal pons responds to bodily threats and transmits alarm signals to the forebrain. Parabrachial neuron activity is enhanced during chronic pain, and inactivation of PBN neurons in mice prevents the establishment of neuropathic, chronic …

2020年9月9日 · The parabrachial nucleus (PBN) is one of the major targets of spinal projection neurons and plays important roles in pain. However, the architecture of the spinoparabrachial pathway underlying its functional role in nociceptive information processing remains elusive. Here, we report that the PBN dir …