First, we describe the protein nature of the PcG body and the gene silencing factory model. Second, we review the target genes of Polycomb-mediated silencing and discuss their essentiality for the structural nature of the PcG body.

2018年1月1日 · Polycomb bodies are foci of polycomb group (PcG) proteins that have been observed within the nucleus of Drosophila and mammalian cells. Their size and number varies within different cell types, and their distribution is developmentally regulated.

pcg蛋白复合物可被分为两类：多梳抑制复合体1(prc1)和prc2。 PRC2是一种甲基转移酶，负责组蛋白H3Lys27的甲基化，其中H3K27me3在基因组兼性异染色质区域中含量丰富。

2012年4月1日 · Polycomb group (PcG) proteins are concentrated in nuclear foci called PcG bodies. Although some of these foci are due to the tendency of PcG binding sites in the genome to occur in linear clusters, distant PcG sites can contact one another and in some cases congregate in the same PcG body when they are repressed.

Polycomb group (PcG) proteins of the Polycomb repressive complex 1 (PRC1) are found to be diffusely distributed in nuclei of cells from various species. However they can also be localized in intensely fluorescent foci, whether imaged using GFP …

Polycomb group (PcG) proteins of the Polycomb repressive complex 1 (PRC1) are found to be diffusely distributed in nuclei of cells from various species. However they can also be localized in intensely fluorescent foci, whether imaged using GFP fusions to proteins of PRC1 complex, or by conventional immunofluorescence microscopy.

2013年8月12日 · A Polycomb (PcG) body is an orphan nuclear subcompartment characterised by accumulations of Polycomb repressive complex 1 (PRC1) proteins. However, seemingly contradictory reports have appeared that describe the PcG bodies either as protein-based bodies in the interchromatin compartment or chromatin domains.

表观 遗传 调控因子Polycomb复合物蛋白（PcG）被认为与多种癌症的发生有着极大的相关性。Rnf2作为polycomb复合物1（PRC1）中主要的E3连接酶，在多种肿瘤组织中表达水平明显上升。

This review is focused on the nuclear domain termed the Polycomb (PcG) body. We summarize and discuss data reported in the literature on differ- ent components of the PcG body that could form its structural basis. First, we describe the protein na- ture of the PcG body and the gene silencing factory model.

PcG bodies are conspicuous in human osteosarcoma U-2 OS cells where their relative sizes differ from 0.2 to 1.5 μm and their number varies between six and fourteen per nucleus.