Molecular testing for acute myeloid leukemia - PMC
Many molecular tests exist and can be used to detect the molecular changes at gene level. These tests include, but are not limited to, karyotyping, endpoint polymerase chain reaction (PCR), …
The proto-oncogenic miR-106a-363 cluster enhances adverse risk …
1 天前 · We investigated the clinical and functional role of the miR-106a-363 cluster in adult acute myeloid leukemia (AML). ... and each cluster miRNA was quantified using qRT-PCR. AML …
【AJH】AML的MRD检测手段及对治疗决策和新药开发的影响@Me…
2024年10月18日 · aml的mrd检测. 可测量残留病(mrd)与急性髓性白血病(aml)患者的复发风险和长期生存结局密切相关，除了其明确的预后影响外，mrd信息也越来越多地用于指导治疗决策， …
Advantages of a genomic DNA-based next-generation sequencing …
2025年2月27日 · Mutations in the nucleophosmin-1 (NPM1) gene are among the most common molecular aberrations in acute myeloid leukemia (AML). ... /DNA and NGS/cDNA are …
Comparative Analysis of NGS and Digital PCR for Measurable …
2024年11月5日 · Next-generation sequencing (NGS) and digital PCR (ddPCR) represent a potential alternative for MRD assessment in AML, given that they offer high sensitivity and …
Conventional PCR Versus Next Generation Sequencing for
2025年3月1日 · Background/objectives: This PETHEMA PCR-LMA study aimed to evaluate whether mutations detected by NGS (VAF cut-off of ≥5%) correlate with NPM1, FLT3-ITD, …
Revealing the Mysteries of Acute Myeloid Leukemia: From …
In this review, we outlined molecular testing advised for AML diagnosis and measurable residual disease (MRD) assessment in order to translate molecular techniques into clinical practice. …
Effect of FLT3 ligand on the gene expression of TIM-3, HIF1
4 天之前 · Acute Myeloid Leukemia (AML) pathogenesis is driven by the dysregulation of various cell signaling pathways, including the FMS-Like Tyrosine Kinase 3 (FLT3) pathway and its …
Recommendations from the AML molecular MRD expert advisory …
2024年5月23日 · To this end, the European LeukemiaNet (ELN) group published recommendations in 2018 [3], updated in 2021, that standardized the technical and reporting …
IRF1 is a core transcriptional regulatory circuitry member …
2025年3月1日 · Background Acute myeloid leukemia (AML) is a prevalent malignancy of the hematologic system. Despite advancements in therapeutic approaches, significant …