Proprotein convertase subtilisin/kexin type 6 is an protease that in humans is encoded by the PCSK6 gene which is located in chromosome 15. [5] [6] Pcsk6 is a calcium-dependent serine endoprotease that catalyzes the post-translational modification of precursor proteins from its ‘latent’ form to the cleaved ‘active’ form. [5]

2024年12月25日 · PCSK6 (Proprotein Convertase Subtilisin/Kexin Type 6) is a Protein Coding gene. Diseases associated with PCSK6 include Dyslexia and Cardiac Tuberculosis. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Keratinization.

该基因编码枯草杆菌蛋白酶样原蛋白转化酶家族的一个成员，其中包括通过分泌途径的受调节或组成性分支处理蛋白质和肽前体运输的蛋白酶。 编码的蛋白质在 ER 中经历初始自催化处理事件以生成异二聚体，该异二聚体离开 ER 并分类到反式高尔基体网络，在该网络中发生第二个自催化事件并获得催化活性。 编码的蛋白酶组成性分泌到细胞外基质中，并在许多组织中表达，包括神经内分泌、肝脏、肠道和大脑。 该基因编码七个碱性氨基酸特异性成员之一，这些成员在单个或成 …

2020年1月2日 · PCSK6 is a novel protease that induces SMC migration in response to PDGFB, mechanistically via modulation of contractile markers and MMP14 activation. This study establishes PCSK6 as a key regulator of SMC function in vascular remodeling. An online visual overview is available for this article. Editorial, see p 586. Meet the First Author, see p 568

2022年11月3日 · Proprotein convertase subtilisin/kexin 6 (PCSK6) is a secreted serine protease expressed in most major organs, where it cleaves a wide range of growth factors, signaling molecules, peptide hormones, proteolytic enzymes, and adhesion proteins. Studies in Pcsk6 -deficient mice have demonstrated …

PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling. PCSK6, a gene that has been implicated in the ontogenesis of bodily asymmetries by regulating the nodal cascade, is also relevant for structural asymmetries in the human brain.

2023年6月1日 · PCSK6 protein was highly expressed in IPF lung parenchyma. PCSK6 lung staining intensity, peripheral blood gene expression, and plasma concentration were associated with reduced TFS. Conclusions: We identified four novel variants associated with IPF survival, including one in PCSK6 that reached genome-wide significance.

PCSK6, also known as paired basic amino acid cleaving enzyme 4 (PACE4) or subtilisin-like proprotein convertase 4 (SPC4), is a member of the PCSK family. PCSK6-mediated protein cleavage has been implicated in diverse biological processes, ranging from embryonic development to tissue senescence.

2024年6月17日 · This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway.

2023年7月28日 · MS/MS研究显示，在250例病例中，有5例出现了新型蛋白质前蛋白转化酶枯草杆菌蛋白酶/可辛6型（PCSK 6）的高总光谱计数。 使用G蛋白 免疫 沉淀、MS/MS和免疫荧光的验证队列在另外8例病例中检测到PCSK6。 所有病例均为已知抗原阴性。 1 3例患者中有10例有大量使用非甾体抗炎药的病史，其中1例无相关病史。 磷脂酶A2受体 (PLA2R)阴性膜性肾病 (MN)中枯草素/酮素6型蛋白转化酶 (PCSK6)的蛋白质组学鉴定. 肾活检的平均血清肌酐和蛋白尿分别 …