Characterization of PCSK9 in the Blood and Skin of Psoriasis
In our study, we observed positive PCSK9 staining in both human and the K14-Rac1V12 −/+ murine model of psoriasis. These finding are similar to a 2019 study describing preferential …
PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to ... - Nature
2024年3月30日 · Immunofluorescence staining of PCSK9 (red, upper panels; N = 3), p-Syk (gray, middle panels; N = 4), and p-PKCδ (green, bottom panels; N = 3). AdV-PCSK9 increased …
STTT：复旦大学全面回顾“明星靶点”PCSK9的前世今生_澎湃号·湃 …
2024年1月9日 · 近日，复旦大学附属浦东医院鲍旭辉研究员团队在《Signal Transduction and Targeted Therapy》发表综述性论文“Targeting proprotein convertase subtilisin/kexin type 9 …
Characterization of PCSK9 in the Blood and Skin of Psoriasis
Despite no difference in hepatocyte expression, K14-Rac1V12-/+ mice demonstrated skin-specific PCSK9 staining, which was confirmed in human psoriatic lesional skin. In patients with …
PCSK9 with a gain of function D374Y mutation aggravates
2025年2月26日 · En face aortic and aortic sinus plaque areas were examined in four groups of mice using Oil Red O staining. Remarkably, in WT mice, PCSK9 DY infection led to larger …
PCSK9 promotes vascular neointimal hyperplasia through non …
2025年1月1日 · PCSK9 is upregulated in carotid ligation model and PDGF-BB-treated MOVAS cells model. Ligation-induced intimal hyperplasia is alleviated in Evolocumab-treated wild type …
Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) …
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a soluble protein that directs membrane-bound receptors to lysosomes for degradation. In the most studied example of this, PCSK9 …
In vivo PCSK9 gene editing using an all-in-one self-cleavage AAV …
In this study, we have engineered an all-in-one self-cleavage AAV-CRISPR-Cas9 system to restrict the expression of Cas9 nuclease, which consists of a Cas9 nuclease from …
PCSK9 increases vulnerability of carotid plaque by promoting ...
2024年2月25日 · Propidium iodide (PI) staining was performed to explore direct evidence to support that PCSK9 regulates apoptosis in living VSMCs. The results showed that increased …
PCSK9 exacerbates sevoflurane-induced neuroinflammatory …
PCSK9 has been shown to be involved in neuronal development and apoptosis, so the proliferation and apoptosis of BV2 cells were examined. EUD staining showed that sevoflurane …