靶点梳理丨CD28卷土重来 - 知乎 - 知乎专栏
CD28是PD-1疗法有效杀死癌细胞和消除小鼠慢性病毒感染的必要条件。 对PD-1疗法有反应的肺癌患者有更多的CD28+T细胞，这表明CD28可能预测治疗反应。 2019年11月，赛诺菲在Nature …
T cell costimulatory receptor CD28 is a primary target for PD-1 ...
2017年3月31日 · By titrating PD-1 signaling in a biochemical reconstitution system, we demonstrate that the co-receptor CD28 is strongly preferred over the TCR as a target for …
T cell costimulatory receptor CD28 is a primary target for PD-1
By titrating PD-1 signaling in a biochemical reconstitution system, we demonstrate that the co-receptor CD28 is strongly preferred over the TCR as a target for dephosphorylation by PD …
Rational design of PD-1-CD28 immunostimulatory fusion proteins …
2023年7月4日 · We now took advantage of a PD-1-CD28 IFP as a clinically relevant structure to define key determinants of IFP activity. We compared different PD-1-CD28 IFP variants in a …
PD-1免疫疗法灵不灵，CD28/B7通路是关键！ - 搜狐
2017年4月7日 · 因而，在本文研究中证实了 pd-1活化后可直接靶向cd28的胞质区域，且具有比t细胞受体下游分子更高的亲和力，进一步强调了cd28和pd-1通路之间的相互作用 ，为pd-1定向 …
PD-1 targets CD28 - Nature Immunology
2017年4月18日 · In Science, Kamphorst et al. and Hui et al. identify the T cell costimulatory receptor CD28 as the relevant target of PD-1-mediated inhibition. The former study shows that …
Cancer Cell | 南开大学院士团队揭示靶向CD28/PD-L1促进三阴性乳 …
结果表明，敲除癌细胞中的cd28可以激活抗肿瘤cd8+ t细胞反应，抑制肿瘤生长，并克服对pd-1抗体的抗性（图1）。 此外，研究还揭示了CD28在癌细胞中的非典型定位，主要在细胞质和核 …
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28 ...
2017年3月31日 · Programmed cell death-1 (PD-1)-targeted therapies enhance T cell responses and show efficacy in multiple cancers, but the role of costimulatory molecules in this T cell …
PD-1 blockade-unresponsive human tumor-infiltrating CD8
2020年4月24日 · Recently, reinvigoration of exhausted CD8 + T cells following PD-1 blockade was shown to be CD28-dependent in mouse models. Herein, we examined the role of CD28 in …
Science子刊封面论文：PD-1抗体“有力搭档”——CD28双特异性抗 …
6月24日，再生元在Science Translational Medicine以封面论文的形式发表了有关CD28双特异性抗体联合PD-1抗体的新研究进展。 研究人员在动物模型中进行的临床前研究中发现，新型CD28 …