2021年8月23日 · Programmed cell death-1 (PD-1) Co-inhibitory checkpoint receptor 1 of 5 receptors within the CD28 coreceptor family [CD28, inducible T cell costimulatory (ICOS), cytotoxic T lymphocyte associated antigen 4 (CTLA4), B and T lymphocyte associated (BTLA)] that regulate the balance between T cell activation and immune tolerance

PD-L1 expression by tumor cells and TILs assessed by immunohistochemistry (IHC) is considered the most reliable predictive marker for response to immunotherapy in different tumor types [12, 13, 14, 15, 16, 17]. Along with therapeutic monoclonal antibodies, several immunohistochemical assays have been created for PD-L1 evaluation.

PD-L1免疫组化检测 是预测PD-1或PD-L1疗效的一种简单有效的方法，它是通过检测肿瘤细胞（TC）或免疫细胞（IC）表面的PD-L1表达量，进而推测PD-L1抑制剂疗效的方法。 目前，PD-L1免疫组化检测试剂盒/抗体有 6 种：SP263、22C3、28-8、SP142、73-10和E1L3N（在实验室中常用）。 不同抗体需要用不同的检测平台检测，主流检测平台为两家公司的5种抗体检测平台，分别为 DAKO 22C3 、28-8和73-10检测的AutoStainer Link 48平台和 Ventana SP142 …

2021年10月25日 · Each checkpoint pathway decreases immune activation through intracellular signaling mechanisms and thus negatively regulates the effector immune cells by inducing T cell regression and exhaustion. Inhibitory checkpoint proteins, including programmed PD-1, PD-L1, or CTLA-4, can suppress antitumor T-cell responses [5, 6]. Enhancement of these ...

PD1是一种在活化的 T 细胞中表达的免疫抑制受体，参与调节 T 细胞功能，在诱导和维持对自身的免疫耐受中起关键作用。 PD-L1 可结合活化T细胞表面的B7.1和PD1 降低细胞毒性。 PD1/PD-L1 相互作用可以通过限制自身的免疫反应调节自身免疫。 PD1/PD-L1通路与适应性免疫抑制的发展有关，其中 PD-L1的过表达能够响应抗肿瘤活性。 PD1介导的抑制通路被肿瘤利用来减弱抗肿瘤免疫，并逃避免疫系统监控，从而促进肿瘤存活。 通过抑制PD1介导的信号通路，可以介导耗尽 …

2024年1月22日 · PD-1（Programmed cell death protein 1，程序性死亡受体1），又称CD279（分化簇 279）， 是人类体内由 PDCD1 基因编码的蛋白质。 PD-1是T细胞和B细胞上的细胞表面受体，其通过抑制T细胞炎症活动，可以下调免疫系统并促进自我耐受以调节免疫系统对人体细胞的反应。 这可以预防自身免疫性疾病，但也可以阻止免疫系统杀死癌细胞。 PD-L1（Programmed Death-ligand 1，程序性死亡配体1）， 也称为分化簇 274 (CD274) 或 B7 同源物 1 (B7-H1) ， …

Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. Binding of PD-1 to its ligand, programmed death-ligand 1 (PD-L1), activates downstream signaling pathways and inhibits T cell activation.

5 天之前 · Some reports have suggested that positive PD-1 expression by IHC on tumor infiltrating lymphocytes (TILs) may predict better outcome after ICIs 20. However, the exact mechanisms underlying the ...

2021年2月12日 · PD-L1 expression, which can be detected using immunohistochemistry (IHC), is found on both tumour cells and immune cells and is a useful, yet imperfect, predictive biomarker of response to anti...

2018年6月26日 · Several immunohistochemistry (IHC) assays have been developed to assess tumor programmed death-ligand 1 (PD-L1) expression levels in patients who are candidates for programmed death-1...