Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy due to the lack of early diagnosis and limited response to treatments. It is the most prevalent type of pancreatic neoplasm, and it is developed in the exocrine compartment and accounts for more than 90% of pancreatic cancer cases.

Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is the fourth leading cause of cancer-related deaths in the world. Due to the broad heterogeneity of genetic mutations and dense stromal environment, PDAC belongs to one of the most chemoresistant cancers.

PDAC remains one of the most aggressive forms of cancer worldwide, with a high cancer-related mortality rate, a five-year survival of less than 8%, and increased chemoresistance observed leading to a poorer prognosis for patients.

2021年12月17日 · Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our understanding of the biology of PDAC have revealed new opportunities for early detection and targeted therapy of PDAC.

Histologically, pancreatic ductal adenocarcinoma (PDAC) accounts for 80% of all pancreatic cancers; the majority of which are... ... Hitherto, clinical progress in PDAC treatment has depended...

Single-nucleotide mutations in the KRAS gene are detected in the majority of patients with pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer.

4 天之前 · Figure 2 showed that the ... Bioinformaitics analysis have shown that COL12A1 expression is linked to poor prognosis in pancreatic cancer, especially PDAC patients 23,24. In addition, experimental ...

2025年4月1日 · Pancreatic cancer metabolism produces a high level of lactate, which changes tumor immune features by protein lactylation and thus results in immunotherapy resistance. ... Figure 1. Lactate-induced ENSA-K63 lactylation drives the formation of an immunosuppressive microenvironment in PDAC. ... In PDAC cells, lactate, generated by LDH during ...

2024年7月1日 · Pancreatic ductal adenocarcinoma (PDAC) is currently the fourth leading cause of death in the United States and is expected to be ranked second in the next 10 years due to poor prognosis and a rising incidence. Distant metastatic PDAC is associated with the worst prognosis among the different phases of PDAC.

2025年2月11日 · PDAC is the most common type of pancreatic cancer, accounting for over 90% of cases 1. It is notorious for its late detection and rapid progression, making it the fourth leading cause of cancer-related deaths worldwide1.