2020年5月11日 · In this Review, we discuss our current understanding of the three principal constituents of PDAC stroma, their effect on the prevalent immune landscape and promising therapeutic targets within ...

2024年1月1日 · Drug resistance in PC is driven by its desmoplastic stroma, which creates a barrier that shields cancer niches and prevents the penetration of drugs. The PC stroma comprises heterogeneous cellular populations and non-cellular components involved in aberrant ECM deposition, immunosuppression, and drug resistance.

2020年10月30日 · It is increasing clear that the extensive fibro-inflammatory stroma (or desmoplasia) of PDAC plays an active role in the progression and therapeutic resistance of PDAC.

胰腺导管腺癌 (PDAC)是西方国家癌症相关死亡的主要原因，治疗选择有限，长期生存惨淡。 肿瘤上皮存在于致密基质中，通过对癌细胞的直接影响和对肿瘤免疫微环境的间接影响，被认为是疾病进展的关键中介。 -PDAC基质中的三个主要实体是细胞外基质 (ECM)、脉管系统和癌症相关的成纤维细胞 (CAFs)。 -ECM可以作为PDAC癌细胞有效药物传递的屏障，在过去的十年中，人们尝试了多种针对ECM的策略。 -肿瘤血管系统是一个复杂的系统，尽管多种抗血管生成药物 …

2025年2月4日 · In summary, we identified a stroma gene signature that differentiates PDAC-PDXs that are responsive to gemcitabine plus Nab-paclitaxel treatment from those that are not, confirming the active role of the tumor microenvironment in the drug response.

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in the Western world with limited therapeutic options and dismal long-term survival. The neoplastic epithelium exists within a dense stroma, which is recognized as a critical mediator of disease progression throug …

2021年4月5日 · The PDAC immune microenvironment is characterized by the exhaustion of anti-cancer immune cytotoxic T lymphocytes notably due to high mechanical constraints within the tumor and the infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells, tumor-associated macrophages and regulatory T cells (10 ...

Pancreatic ductal adenocarcinoma (PDAC) is one of the five most lethal malignancies worldwide and survival has not improved substantially in the past 30 years. Desmoplasia (abundant fibrotic stroma) is a typical feature of PDAC in humans, and stromal activation commonly starts around precancerous le …

2012年6月19日 · Pancreatic ductal adenocarcinoma (PDAC) is one of the five most lethal malignancies worldwide and survival has not improved substantially in the past 30...

The dense dysplastic stroma of PDAC is a major obstacle to the delivery of chemotherapy drugs and plays an important role in the progression of PDAC. Therefore, stroma-targeting therapy is considered a potential treatment strategy to improve the efficacy of …