RCSB Protein Data Bank (RCSB PDB) enables breakthroughs in science and education by providing access and tools for exploration, visualization, and analysis of: These data can be explored in context of external annotations providing a structural view of biology. 3D visualization for PDB structures and ligand binding sites.

2024年9月23日 · Using AK-068 and cereblon ligands, we discovered AK-1690 as the first, potent and selective PROTAC STAT6 degrader. AK-1690 effectively induces degradation of STAT6 protein in cells with DC 50 values of as low as 1 nM while showing minimal effect on other STAT members up to 10 μM. A single dose of AK-1690 effectively depletes STAT6 in mouse ...

It is commonly referred to as PKB, or by both names as "Akt/PKB". The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet -derived growth factor.

2023年4月10日 · PDBsum is a pictorial database that provides an at-a-glance overview of the contents of each 3D structure deposited in the Protein Data Bank (PDB). It shows the molecule (s) that make up the structure (ie protein chains, DNA, ligands and metal ions) and schematic diagrams of the interactions between them.

2016年3月9日 · The Protein Data Bank (PDB)--the single global repository of experimentally determined 3D structures of biological macromolecules and their complexes--was established in 1971, becoming the first open-access digital resource in the biological sciences. The PDB archive currently houses ~130,000 entries (May 2017).

2024年4月23日 · Using AK-068 and cereblon ligands, we discovered AK-1690 as the first, potent and selective PROTAC STAT6 degrader. AK-1690 effectively induces degradation of STAT6 protein in cells with DC 50 values of as low as 1 nM while showing minimal effect on other STAT members up to 10 μM.

2023年2月2日 · Here we report the development of AK-2292 as a first, potent and selective small-molecule degrader of both STAT5A and STAT5B isoforms. AK-2292 induces degradation of STAT5A/B proteins with an...

蛋白质资料库（Protein Data Bank，简称PDB）是一个专门收录蛋白质及核酸的三维结构资料的数据库。由Worldwide Protein Data Bank监管。PDB可以经由网络免费访问，是结构生物学研究中的重要资源。

In the apo/ unligated structure, the ATP-bind and AMP-bind domains assume open conformations (Fig. 2 a ; PDB code 4AKE) (41). A closed conformation (Fig. 2 b ), crystallized with the inhibitor AP...

Using AK-068 and cereblon ligands, we discovered AK-1690 as the first, potent and selective PROTAC STAT6 degrader. AK-1690 efectively induces degradation of STAT6 protein in cells with DC50 values of as low as 1 nM while showing minimal efect on other STAT members up to 10 μM. A single dose of AK-1690 efectively depletes STAT6 in mouse tissues.