RCSB PDB - 3DBA: Crystal structure of the cGMP-bound GAF a …
2008年5月30日 · The photoreceptor phosphodiesterase (PDE6) regulates the intracellular levels of the second messenger cGMP in the outer segments of cone and rod photoreceptor cells. …
RCSB PDB - 3JBQ: Domain Organization and Conformational Plasticity …
2015年9月17日 · The cGMP phosphodiesterase of rod photoreceptor cells, PDE6, is the key effector enzyme in phototransduction. Two large catalytic subunits, PDE6α and -β, each …
RCSB PDB - 6PX0: Crystal structure of the TPR domain of human …
2019年7月24日 · Phosphodiesterase-6 (PDE6) is key to both phototransduction and health of rods and cones. Proper folding of PDE6 relies on the chaperone activity of aryl hydrocarbon …
Photoreceptor phosphodiesterase (PDE6): structure, regulatory ...
The photoreceptor phosphodiesterase (PDE6) is a member of large family of Class I phosphodiesterases responsible for hydrolyzing the second messengers cAMP and cGMP. …
The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6 …
Photoreceptor phosphodiesterase 6 (PDE6) is the central effector of the visual excitation pathway in both rod and cone photoreceptors, and PDE6 mutations that alter PDE6 structure or …
Domain Organization and Conformational Plasticity of the G …
2015年5月5日 · The cGMP-specific PDE6 isozymes of vertebrate rod and cone photoreceptors are unique in containing two tightly bound inhibitory γ subunits (3, 4). PDE6 is a …
Characteristics of Photoreceptor PDE (PDE6): similarities and
2004年6月6日 · PDE6 is the primary regulator of cytoplasmic cGMP concentration in rod and cone photoreceptors (Figure 1). In the dark, PDE6 exists in an inactive form, and cGMP levels …
Cryo-EM structure of phosphodiesterase 6 reveals insights
Rod photoreceptor PDE6 is an atypical phosphohydrolase that consists of a heterodimeric catalytic core composed of PDE6α and PDE6β subunits (PDE6αβ heterodimer) and two …
5T4X: CRYSTAL STRUCTURE OF PDE6D IN APO-STATE - RCSB PDB
2016年8月30日 · To investigate the molecular mechanism of cargo solubilization we analyzed the PrBP/δ-induced membrane dissociation of rod photoreceptor phosphodiesterase (PDE6). The …
Allosteric regulation of rod photoreceptor phosphodiesterase 6 (PDE6 …
2019年9月9日 · Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in the visual excitation pathway in rod and cone photoreceptors. Its tight regulation is essential for …