2022年11月22日 · Here, we report the cryo-electron microscopy structures of the endogenous cubic 2-oxoglutarate dehydrogenase complex (OGDC) and icosahedral pyruvate dehydrogenase complex (PDC) cores from...

The family of 2-oxoacid dehydrogenase complexes (2-OADC), typified by the pyruvate dehydrogenase multi-enzyme complex (PDC) as its most prominent member, are massive molecular machines (M r, 4-10 million) controlling key steps in glucose homeostasis (PDC), citric acid cycle flux (OGDC, 2-oxoglutarate dehydrogenase) and the metabolism of the ...

酮戊二酸脱氢酶（oxoglutarate dehydrogenase complex，缩写OGDC）是一个 复合酶，因其在 三羧酸循环 中的作用而众所周知。 事实上，生物学家已经将类似的 多酶复合体 表征并分成三大类，一类是专门作用于丙 酮酸，第二类专门作用于 α-酮戊二酸，第三类专门作用于 支链 α-酮酸。 中间产物 随后被转移到辅酶A，形成了最终产物，琥珀酰辅酶A. 此反应的ΔG为-7.2 千卡/ 摩尔。 此氧化过程所需的能量以 硫酯 键的形式被保存在琥珀酰辅酶A之中。 酮戊二酸脱氢酶是三羧酸循 …

2017年3月8日 · The family of 2-oxoacid dehydrogenase complexes (2-OADC), typified by the pyruvate dehydrogenase multi-enzyme complex (PDC) as its most prominent member, are massive molecular machines (Mr, 4–10 million) controlling …

2024年11月1日 · Anti-mitochondrial antibodies (AMA), directed against the E2 subunits of the 2-oxo acid dehydrogenase complexes, are markers of Primary Biliary Cholangitis (PBC), a chronic autoimmune liver disease.

酮戊二酸脱氢酶复合体 （英語： oxoglutarate dehydrogenase complex，缩写 OGDC；或稱英語： α-ketoglutarate dehydrogenase complex）是一个复合酶，因其在 三羧酸循环 中的作用而众所周知。 与 丙酮酸脱氢酶复合体 （PDC）十分相似，此酶由三个组件形成一个复合体： 事实上，生物学家已经将类似的多酶复合体表征并分成三大类，一类是专门作用于 丙酮酸，第二类专门作用于 α-酮戊二酸，第三类专门作用于 支链α-酮酸。 此酶参与三种不同的代谢途径. 下列酶参数的值 …

The 2-oxo-acid dehydrogenase complex (2-OADC) is among the best biochemically characterized enzyme. 2-OADC consists of three related complexes, the PDC, OGDC and BCOADC, which are located in the mitochondrial matrix.

The characteristic serological feature of primary biliary cirrhosis (PBC) is the presence of antimitochondrial antibodies (AMAs), and the major proteins recognized by AMAs are subunits of the 2-oxo acid dehydrogenase complexes (2-OADC), including the E2 components of the pyruvate dehydrogenase complex (PDC), the 2-oxo-glutarate dehydrogenase ...

Primary biliary cirrhosis (PBC) is associated with a high incidence of autoantibodies directed at mitochondrial autoantigens (the antimito-chondrial antibodies), identified as the E2 components of PDC, OGDC, and BCOADC, together with protein X …

The family of mammalian 2-oxoacid dehydrogenase complexes (PDC, BCOADC and OGDC) are stable, high Mr assemblies composed of multiple copies of 3 separate enzymes (E1, E2 and E3) that catalyse key stages in carbohydrate and amino acid metabolism.