2023年10月8日 · pDC/IFN导致SLE发病的潜在机制如下：包含自体核酸的免疫复合物、中性粒细胞胞外诱捕网（NETs）等刺激pDC产生I-IFN，IFN一方面作用于多种免疫细胞，如T、B、Th17等，促进自身抗体的产生；另一方面，IFN与受体结合通过激活下游信号通路参与炎性反应。 图1. pDC/IFN导致SLE发生的潜在机制. 靶向pDC的相关药物研发现在也如火如荼，比如Viela Bio公司在美国风湿病学会上公布了VIB7734（ILT-7 mAb）在皮肤型红斑狼疮（CLE）的Ib期疗效数据。

Emerging evidence has highlighted a role for pDCs and type I IFN in human autoimmune conditions. pDCs are highly enriched in affected tissue in several autoimmune conditions where IFN activity is also high, including dermatomyositis, polymyositis, systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE), psoriasis, alopecia ...

2022年10月1日 · In this review, we summarize the activation and function of major DC subsets, cDCs, pDCs and tolDCs, in the pathogenesis of SLE and their potential as targeted treatment of SLE. We also discuss the pathogenic effects of dysregulated DC functions in SLE-related organ inflammations. Fig. 1.

2016年2月16日 · Plasmacytoid dendritic cells (pDCs) were considered to be the major IFNα source in systemic lupus erythematosus (SLE) but their phenotype and function in different...

2020年12月1日 · We show that pDC numbers, TLR-mediated cytokine production, and T-cell-activating capacity are decreased prior to the onset of SLE. This impairment is unrelated to the type I IFN signature in...

2022年8月4日 · Plasmacytoid dendritic cells (pDCs) have an important role in the pathogenesis of systemic lupus erythematosus (SLE). New research attempts to explore the cause of pDC hyperactivation in SLE...

2023年8月9日 · 该研究发现一种新型的BDCA2抗体偶联物（BDCA2-ADC），能够有效地抑制系统性红斑狼疮（Systemic Lupus Erythematosus，SLE）。在SLE中，浆细胞样树突状细胞（pDC）过度产生I型干扰素（IFN-I），而BDCA2/CLEC4C被认为是这种自身免疫反应的关键。

2019年1月15日 · Clinical SLE is associated with the reduction of pDCs in the peripheral blood and their concomitant accumulation in tissue lesions. pDCs can be induced to produce IFN-I by multiple SLE-associated molecular features including nucleic acid-containing immune complexes, complexes of DNA with antimicrobial peptides, neutrophil extracellular traps ...

目的了解系统性红斑狼疮 (SLE)患者外周血中浆细胞样树突状细胞 (pDC)及其相关细胞因子干扰素-α (INF-α),白介素-23 (IL-23)的变化,探讨上述变化的意义. 方法选取符合1997年美国风湿病学会修订的SLE分类标准的SLE患者60例 (SLE组),正常健康人30例 (对照组).取外周静脉血2ml,EDTA抗凝,全血法对标本进行表面荧光染色,利用流式细胞术检测外周血pDC在各组的相对计数;2ml非抗凝血,酶联免疫吸附实验法测定血清中INF-α及IL-23的浓度.比较SLE组与正常对照组外周血pDC相对计数 …

2020年6月16日 · Type I interferon (IFN-I) signaling and IFN-I-producing plasmacytoid dendritic cells (pDCs) facilitate the differentiation of DNA-reactive AFCs in vivo and in vitro and are required for downstream manifestations of autoimmunity.