磷酸二酯酶（pde）具有水解细胞内第二信使（camp,环磷酸腺苷或cgmp,环磷酸鸟苷）的功能，降解细胞内camp或cgmp为5-单磷酸核苷（5’ amp或5’gmp)，从而终结这些第二信使所传导的生化作用。

pdes具有不同的底物专一性：pde 4、7、8专一作用于camp，而pde 5、6、9则选择性地作用于cgmp。 PDE3以相似的亲和力与cAMP和cGMP结合，但相对较少地水解cGMP，因而在功能上被视作对cAMP专一，cGMP通过与酶作用部位的竞争性结合而起 负调控 因子作用。

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.

磷酸二酯酶 (pdes) 是一系列水解 camp 及 cgmp 的水解酶，是调节 camp 和 cgmp 水平的重要环节，针对 pdes 尤其是 pde3 和 pde5 的干预对于 心力衰竭 治疗有着重要意义

2021年1月7日 · Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and cGMP. They are members of a family of proteins that includes 11 subfamilies with...

Phosphodiesterases (PDEs) are enzymes that regulate the intracellular levels of cAMP and cGMP. Protein kinase A or cAMP-dependent protein kinase mediates most cAMP effects in the cell. Over the last 25 years, various components of this group of molecules have been involved in human diseases, both genetic and acquired.

2007年6月8日 · For PDE3, cGMP acts as a competitive inhibitor of cAMP hydrolysis. Several cGMP-mediated responses in cardiac cells, including a potentiation of Ca 2+ currents and a diminution of the responsiveness to β-adrenergic receptor agonists, have been shown to result from the effects of cGMP on cAMP hydrolysis.

2020年11月12日 · 临床药物双嘧达莫可以通过抑制PDE，提高cAMP的浓度，从而提高PKA通路的活性，提高Navie CD8+T细胞的CD39表达，来起到治疗作用（当然，文章中作者使用了细胞实验证实了这些分析推测）。

2018年9月1日 · Aims: Cyclic adenosine 3'5'-monophosphate (cAMP) is a universal second messenger that plays an important role in intracellular signal transduction. cAMP is synthesized by adenylate cyclases from adenosine triphosphate and terminated by the phosphodiesterases (PDEs). In the present study, we investigated the role of the cAMP pathway in tubular ...

Phosphodiesterase (PDE) is key enzymes in the adenosine and guanosine cyclic nucleotides (cAMP and cGMP) signaling cascade, acts by breaking the phosphodiester bond. Phosphodiesterase (PDE) is a large family with multiple genes. The development of selective phosphodiesterase inhibitors will open up new ideas for many diseases research.