A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.

PDE families contain many splice variants that mostly are unique in tissue-expression patterns, gene regulation, enzymatic regulation by phosphorylation and regulatory proteins, subcellular localization, and interaction with association proteins.

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2021年1月7日 · Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and cGMP. They are members of a family of proteins that includes 11 subfamilies with...

2007年2月16日 · A number of splice variants have been identified in each PDE family, as described here. In regard to certain variants of classical PDEs (PDE1 to -6), molecular characteristics, tissue expression patterns, and expression regulation, all of which are indispensable information to figure out PDE functional roles in cells, have to some extent been ...

2021年11月3日 · PDEs constitute a large and complex superfamily that contains 11 PDE gene families (PDE1 to PDE11), comprising 21 genes that generate approximately 100 (or more) proteins via alternative splicing of mRNA or multiple promoters and transcription start sites (Figures 2 and 3) (4, 5).

Phosphodiesterases (PDEs) are known as a super-family of 11 isoenzymes, which can exert various functions based on their organ distribution. Aside from non-selective PDE inhibitors (methylxanthines, e.g. theophylline) used many years in clinical settings, increasing attention is focused on the involvement of selective PDE inhibitors in therapy ...

2014年4月1日 · Eleven families of PDEs, containing at least 25 genes, are each defined based on differences in their sequence, substrate specificity, regulatory characteristics, inhibitor sensitivity and tissue...

2010年1月1日 · There are 11 known phosphodiesterase (PDE) gene families, each with their own distinct characteristics. The phosphodiesterases share the same organizational structure. Each protein has an N-terminal domain that confers regulatory properties to the protein, followed by a more C-terminal ∼270 amino acid catalytic domain and a short C-terminal tail.

Each PDE family encompasses one to four distinct genes, giving rise to more than 20 genes in mammals that encode more than 50 different PDE proteins that are all probably expressed in mammalian cells (Lugnier, 2006; Conti and Beavo, 2007; Francis et al., 2011). PDE isozymes generally exist as dimers.