Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5 ′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and calmodulin-dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase (PDE1-PDE11).

PDE1 is a dual substrate (cAMP and cGMP) diesterase and a promising target for the treatment of heart disease, cancer, neurological disorder and other endocrine abnormalities.

PDEs 1和．2既能水解cAMP，又能水解cGMP，但PDE1因其亚型不同，对两种 底物 发挥不同的水解效能。PDEs的氨基端调控区域具有高度异源性，反映PDE家族成员的不同的辅助因子。此区域是与钙调蛋白(CaM )(PDE1)、非催化的cGMP (PDE2、5、6)和 转导子 (transducin)(PDE6)相结 …

As a Class 1 phosphodiesterase, PDE1 hydrolyzes the 3' bond of 3'-5'-cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Here, we review evidence for this family of enzymes as drug targets for development of therapies aimed to address disorders of the central nervous system (CNS) and of ...

2024年12月25日 · PDE1A (Phosphodiesterase 1A) is a Protein Coding gene. Diseases associated with PDE1A include Fraser Syndrome 1 and Nephrolithiasis. Among its related pathways are Calmodulin induced events and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include calmodulin binding and cGMP binding.

2022年10月7日 · 磷酸二酯酶 1 （ phosphodiesterases 1, PDE1 ）是磷酸二酯酶家族的成员之一，可同时水解第二信使 cAMP 和 cGMP ，高表达于脑组织。 PDE 蛋白介导的相关信号通路参与了炎症与神经损伤。

2017年9月28日 · The focus of this chapter is on the cyclic nucleotide phosphodiesterase 1 (PDE1) family. PDE1 is one member of the 11 PDE families (PDE 1–11). It is the only phosphodiesterase family that is calcium/calmodulin activated.

PDE1 (phosphodiesterase1) is a phosphodiesterase enzyme also known as calcium - and calmodulin -dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase (PDE1-PDE11). PDE1 has three subtypes, PDE1A, PDE1B and PDE1C which divide further into various isoforms.

环核苷酸磷酸二酯酶 (PDE) 通过将 cAMP 和/或 cGMP 水解成各自的核苷 5-主要单磷酸来调节细胞内环核苷酸浓度，从而在信号转导中发挥作用。 PDE1 家族的成员，例如 PDE1A，是 CA (2+) /钙调蛋白 (参见 CALM1；MIM 114180) 依赖性 PDE (CaM-PDE) ，在 CA (2+) 存在的情况下被钙调蛋白激活 (Michibata 等 al., 2001 [PubMed 11342109]；Fidock 等人，2002 [PubMed 11747989]) . [OMIM 提供，2009 年 10 月]

PDE1 is a group of enzymes that require both calcium and calmodulin for their activity. They are encoded by three genes in humans and are involved in the degradation of cyclic nucleotides, specifically cGMP and cAMP. The exact function of PDE1 in the airways smooth muscle is currently unknown.