PDE10A is a regulatory protein involved in the signaling of the striatum, a region of the brain important for controlling movement and cognition. Dysfunction of the striatum has been linked …

2024年12月25日 · PDE10A (Phosphodiesterase 10A) is a Protein Coding gene. Diseases associated with PDE10A include Striatal Degeneration, Autosomal Dominant 2 and …

2022年5月4日 · pde10a是pde家族的成员，其主要在中枢神经系统内的纹状体中型多棘神经元表达。 针对PDE10A选择性抑制剂的开发是当前治疗相关神经及精神类疾病的热门方向。

该基因编码的蛋白质属于环核苷酸磷酸二酯酶家族。 它通过调节细胞内环核苷酸的浓度在信号转导中发挥作用。 该蛋白可将 cAMP 和 cGMP 均水解为相应的核苷 5'一磷酸，但对 cAMP 具有更 …

磷酸二酯酶10A（PDE10A）是磷酸二酯酶第10家族中的唯一成员，水解第2信使cAMP和cGMP，从而参与许多细胞内信号转导通路的调节。 PDE10A在大脑纹状体中的高表达，提示 …

PDE10A is a dual cAMP/cGMP hydrolyzing enzyme which has triggered considerable interest over the last few years thanks to its high expression in the brain and in particular in the striatal …

2025年2月9日 · Phosphodiesterase 10A (PDE10A) as a novel target to suppress beta-catenin and RAS signaling in epithelial ovarian cancer. Role of PDE10A in vascular smooth muscle …

2022年7月16日 · Our findings show that PDE10A expression is most abundant in the sensorimotor striatum, intermediate in the associative striatum and lower in the limbic striatum. …

Phosphodiesterase 10A (PDE10A) is a basal ganglia specific hydrolase, which plays an essential role in regulating cAMP/PKA and cGMP/PKG signalling cascades by controlling the …

2021年1月20日 · PDE10A, a phosphodiesterase that inactivates both cAMP and cGMP, is a unique signaling molecule in being highly and nearly exclusively expressed in striatal medium …