PDE10A - Wikipedia
PDE10A is a regulatory protein involved in the signaling of the striatum, a region of the brain important for controlling movement and cognition. Dysfunction of the striatum has been linked …
PDE10A Gene - GeneCards | PDE10 Protein | PDE10 Antibody
Dec 25, 2024 · PDE10A (Phosphodiesterase 10A) is a Protein Coding gene. Diseases associated with PDE10A include Striatal Degeneration, Autosomal Dominant 2 and Dyskinesia, Limb And …
【APSB推荐】神经靶点PDE10A的PET药物研发领域最新研究成果
May 4, 2022 · pde10a是pde家族的成员，其主要在中枢神经系统内的纹状体中型多棘神经元表达。 针对PDE10A选择性抑制剂的开发是当前治疗相关神经及精神类疾病的热门方向。
PDE10A inhibitors: novel therapeutic drugs for schizophrenia
Phosphodiesterase 10A (PDE10A) is a basal ganglia specific hydrolase, which plays an essential role in regulating cAMP/PKA and cGMP/PKG signalling cascades by controlling the …
PDE10A - an overview | ScienceDirect Topics
PDE10A is a dual cAMP/cGMP hydrolyzing enzyme which has triggered considerable interest over the last few years thanks to its high expression in the brain and in particular in the striatal …
磷酸二酯酶 10A（PDE10A）基因 | MCE - MCE-生物活性分子大师
该基因编码的蛋白质属于环核苷酸磷酸二酯酶家族。 它通过调节细胞内环核苷酸的浓度在信号转导中发挥作用。 该蛋白可将 cAMP 和 cGMP 均水解为相应的核苷 5'一磷酸，但对 cAMP 具有更 …
磷酸二酯酶10A及其研究进展 - shsmu.edu.cn
磷酸二酯酶10A（PDE10A）是磷酸二酯酶第10家族中的唯一成员，水解第2信使cAMP和cGMP，从而参与许多细胞内信号转导通路的调节。 PDE10A在大脑纹状体中的高表达，提示 …
Phosphodiesterase 10A (PDE10A): Regulator of Dopamine …
Jul 16, 2022 · Our findings show that PDE10A expression is most abundant in the sensorimotor striatum, intermediate in the associative striatum and lower in the limbic striatum. The …
Circulation：PDE10A在心室重构和心衰中的作用 - MedSci.cn
tp-10治疗可升高心肌细胞和心肌成纤维细胞的camp和cgmp的水平，与pde10a作为camp/cgmp双特异性pde一致。在体内，pde10a缺乏显著减轻了由横主动脉缩窄引起的慢性压力超负荷或经 …
药渡Cyber解析默克开发的PDE10A抑制剂MK-8189分子设计和优化 …
PDE10A，是纹状体信号通路的重要调节体，当其受到抑制后，能够改善纹状体的失常状态，因而成为精神分裂症治疗的一个新的潜在靶点。 默克 公开了高活性和高选择性的PDE10A抑制剂 …
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