Nitric oxide activates AMPK by modulating PDE3A in human pulmonary ...
Phosphodiesterase 3 (PDE3), of which there are two isoforms, PDE3A and PDE3B, hydrolyzes cAMP and cGMP-cyclic nucleotides important in the regulation of pulmonary vascular tone. …
Nitric oxide activates AMPK by modulating PDE3A in human …
2020年9月10日 · We found that in hPASMC, NO treatment increased PDE3A protein expression and PDE3 activity with a concomitant decrease in cAMP concentrations and increase in AMPK …
Cyclic nucleotide phosphodiesterases: New targets in the …
2020年4月1日 · In heart failure (HF), endothelial dysfunction has a major effect on PDE3 function, and PDE3 inhibition restores functional relaxation after β-adrenoceptor stimulation (Hubert et …
White to beige conversion in PDE3B KO adipose tissue through
2017年1月13日 · In this report, we show that targeted inactivation of the murine SvJ129 Pde3b gene was associated with activation of cAMP/PKA and AMPK signaling pathways, the …
Regulation of AMP-activated protein kinase by cAMP in
2009年5月1日 · Phosphodiesterase 3B (PDE3B) is a critical regulator of cAMP signaling in adipocytes. Here we investigated the roles of PDE3B, PDE4, protein kinase B (PKB) and the …
Pde3a and Pde3b regulation of murine pulmonary artery smooth …
2024年10月22日 · Both PDE3A and PDE3B subtypes have been shown to regulate AMP-activated protein kinase (AMPK), an ubiquitously expressed serine/threonine protein kinase …
Treatment Of Human Pulmonary Microvascular Endothelial Cells with …
2021年3月1日 · In varying cell types, PDE3 inhibition has been shown to increase endothelial nitric oxide synthase (eNOS) expression and activation via AMP-activated protein kinase …
(PDF) Nitric oxide activates AMPK by modulating PDE3A in human ...
2020年9月1日 · We found that in hPASMC, NO treatment increased PDE3A protein expression and PDE3 activity with a concomitant decrease in cAMP concentrations and increase in AMPK …
Phosphodiesterase 3 (PDE3), of which there are two isoforms, PDE3A and PDE3B, hydrolyzes cAMP and cGMP—cyclic nucleotides important in the regulation of pul-monary vascular tone. …
通过激活AMPK信号传导和线粒体功能，PDE3B KO脂肪 ... - X-MOL
为了研究环核苷酸对能量稳态机制的影响，通过环核苷酸磷酸二酯酶3b（Pde3b）基因的靶向失活产生了小鼠，该基因编码PDE3B，该酶催化cAMP和cGMP的水解并在调节能量稳态的组织中 …
- 某些结果已被删除