2018年1月31日 · The ability of cAMP to elicit cell surface receptor-specific responses relies on its compartmentalisation by cAMP hydrolysing enzymes known as phosphodiesterases. One …

pdes具有不同的底物专一性：pde 4、7、8专一作用于camp，而pde 5、6、9则选择性地作用于cgmp。pde3以相似的亲和力与camp和cgmp结合，但相对较少地水解cgmp，因而在功能上被 …

2024年5月31日 · pde是唯一降解细胞内环状腺苷单磷酸（camp）和环状鸟苷单磷酸（cgmp）等第二信使的酶，包含11个家族成员（pde1~pde11）。其中，pde4专一性水解camp。pde4包含4 …

The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a …

Although cardiac myocytes have taken centre stage in terms of PDE4 research, this group of enzymes also has major roles in the wider cardiovascular system, regulating many …

2003年2月15日 · PDE4 cAMP-specific phosphodiesterases appear to have specific functions with selective inhibitors serving as potent anti-inflammatory agents. The recent elucidation of the …

4 天之前 · Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium handling, and …

2023年5月10日 · 磷酸二酯酶4(phosphodiesterase4, PDE4)是磷酸二酯酶家族中重要成员之一，可特异性水解环磷酸腺苷(cyclic adenosine monophosphate, cAMP)，通过改变cAMP浓度引发 …

Inhibition of PDE4 is predicted to have diverse effects via the elevation of the level of cyclic adenosine monophosphate (cAMP) and the subsequent regulation of a wide array of genes …

2022年9月13日 · The PDE4 family, which exclusively hydrolyses the cAMP (K m = 2–4 µM), is the most extensive family, coded by four genes, namely PDE4A to PDE4D. Each gene encodes …