The Molecular Biology of Phosphodiesterase 4 Enzymes as ... - PubMed
The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a …
PDE4 inhibitor - Wikipedia
A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine …
Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory ...
Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and epithelial …
Phosphodiesterase-4 enzyme as a therapeutic target in …
2020年10月1日 · Phosphodiesterase 4 (PDE4) is the major isoform within this group and is highly expressed in the mammalian brain. An inverse association between PDE4 and cAMP levels is …
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological …
The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a …
PDE4D: A Multipurpose Pharmacological Target - PMC
Phosphodiesterase 4 (PDE4) enzymes catalyze cyclic adenosine monophosphate (cAMP) hydrolysis and are involved in a variety of physiological processes, including brain function, …
PDE4 Phosphodiesterases in Cardiovascular Diseases: Key ...
Through the fine-tuning of cAMP signaling, PDE4 enzymes could play an important role in cardiac hypertrophy and arrhythmogenesis, while it decisively influences vascular homeostasis …
磷酸二酯酶 4 | Phosphodiesterase-4 (PDE4) | MCE - MCE-生物活性 ...
磷酸二酯酶 4 (PDE4)，是一种属于 Phosphodiesterase (PDE) 的酯酶，负责降解 cAMP and cGMP。磷酸二酯酶 4 降解环磷酸腺苷参与调节促炎细胞因子。 磷酸二酯酶 4 降解环磷酸腺 …
The multifaceted role of phosphodiesterase 4 in tumor: from ...
2025年3月10日 · Phosphodiesterase 4 (PDE4) is an enzyme that specifically hydrolyzes the second messenger cAMP and has a critical role in the regulation of a variety of cellular …
Role of phosphodiesterases in the pathophysiology of …
2021年1月7日 · Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and cGMP. They are members of a family of proteins that includes 11 subfamilies with...