The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a …

The PDE4 family is encoded by four genes, PDE4A, PDE4B, PDE4C and PDE4D, collectively yielding over 20 different proteins generated by the use of different promoters and by …

The PDE4 family, which exclusively hydrolyses the cAMP (K m = 2–4 µM), is the most extensive family, coded by four genes, namely PDE4A to PDE4D. Each gene encodes multiple protein …

PDE families contain many splice variants that mostly are unique in tissue-expression patterns, gene regulation, enzymatic regulation by phosphorylation and regulatory proteins, subcellular …

2025年3月20日 · The PDE4 family is essential in regulating cardiomyocyte physiology and pathophysiology, intricately balancing localised cAMP signalling [6,7,67,71,72,93]. In the heart, …

2007年2月16日 · The 3 isoforms in the PDE4 family are illustrated and boxed. PDE3 enzymes produced by alternative translation initiation are boxed. Reported phosphorylation sites are …

PDE4 is the major regulator of cAMP levels in leukocytes and other inflammatory cells (Barnette 1999). Inhibition of PDE4 increases intracellular cAMP concentrations which ultimately results …

2025年3月10日 · However, the PDE4 family may have both oncogenic and tumor-suppressive effects, which could depend on the specific type and grade of the tumor. PDE4 inhibitors have …

2025年3月20日 · Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium …

2006年3月1日 · The PDE4 family, which exclusively hydrolyzes cAMP (K m = 2–4 μM), contains a unique signature region of amino acid sequence, called upstream conserved region 1 and 2 …