A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors .

2023年6月26日 · Caffeine exerts its effects on phosphodiesterase enzymes by nonselective inhibition of PDE1, PDE4, and PDE5, promoting cAMP accumulation. Caffeine also inhibits adenosine and gamma-aminobutyric acid (GABA) receptors and enhances intracellular calcium release, improving and enhancing cognition, memory, energy, sleep, fatigue, and drowsiness.

2025年3月4日 · PDE4 inhibitors. PDE4 inhibitors work by increasing the levels of cAMP. They specifically target the airways, the skin and immune system, and the brain. PDE4 inhibitors work by causing smooth muscle relaxation in the airways, making them useful in the treatment of pulmonary diseases, such as asthma and chronic obstructive pulmonary disease.

Targeting PDE4 has been verified as an effective therapeutic strategy for inflammatory conditions, including asthma, chronic obstructive pulmonary disease (COPD), psoriasis, atopic dermatitis (AD), inflammatory bowel diseases (IBD), rheumatic arthritis (RA), lupus, and neuroinflammation (as shown in Figure 1).

Understand the mechanism of action (MOA) of Otezla® (apremilast), a PDE4 inhibitor. Otezla dials down inflammatory drivers. Watch videos, review additional information, and test your knowledge of the MOA for Otezla for adults with plaque psoriasis, psoriatic arthritis, and oral ulcers in Behçet's Disease.

In this review, we present a summary of an emerging class of selective PDE4B/D inhibitors under clinical development and compare the differences in selectivity of this new generation of PDE4 inhibitors with the less selective currently approved PDE4 inhibitors.

2020年4月7日 · Cyclic nucleotide phosphodiesterase 4 (PDE4) specifically hydrolyzes cyclic adenosine monophosphate (cAMP) and plays vital roles in biological processes such as cancer development. To date, PDE4 inhibitors have been widely studied as therapeutics for the treatment of various diseases such as chronic obstructive pulmonary disease, and many of ...

The inhibitory action of PDE4 inhibitors on the cellular activity of CD8 + T lymphocytes and macrophages was significantly increased in the presence of PDE7 selective inhibitors (Smith et al., 2004). Similarly, combined PDE3 and PDE4 inhibitor in a single molecule offers the advantage of delivering a bronchodilator and anti-inflammatory substance.

2013年4月4日 · Advancements in phosphodiesterase (PDE)-targeted therapies have shown promise in recent years for treating patients with a variety of autoimmune diseases. This review summarizes the development of PDE4 inhibitors and the associated literature with a focus on treatments for autoimmune diseases.

The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as i …