Enhancing intracellular cAMP levels by inhibiting PDE4 has been proven to be an available therapeutic strategy to alleviate several diseases in which inflammation plays a critical role, such as pulmonary, dermatological, and severe neurological …

The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as i …

2005年11月15日 · In this review we will discuss the cellular and molecular biology of PDE4 isoforms (of which ∼20 have been characterized) and, in particular, the pivotal role that PDE4 isoforms play in achieving compartmentalized signaling in …

2025年2月4日 · PDE4 plays a central role in modulating inflammatory responses by regulating cAMP levels in immune cells, including T lymphocytes, macrophages, and dendritic cells. Elevated PDE4 activity leads to reduced intracellular cAMP levels, which enhances the production of proinflammatory cytokines such as TNF-α, IL-6, and IL-1β [19].

Selective PDE4D inhibitors (PDE4Dis) could represent an innovative and valid therapeutic strategy for the treatment of various neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Huntington’s, and Lou Gehrig’s diseases, but also for stroke, traumatic brain and spinal cord injury, mild cognitive impairment, and all demyelinating disease...

2023年3月15日 · Phosphodiesterase 4 (PDE4) hydrolyzes cyclic adenosine monophosphate (cAMP) and plays a vital roles in many biological processes. PDE4 inhibitors have been widely studied as therapeutics for the treatment of various diseases, including asthma, chronic obstructive pulmonary disease (COPD) and psoriasis.

2025年3月10日 · Abstract Phosphodiesterase 4 (PDE4) is an enzyme that specifically hydrolyzes the second messenger cAMP and has a critical role in the regulation of a variety of cellular functions. In recent years, PDE4 has attracted great interest in cancer research, and its role in tumorigenesis and development has been gradually elucidated. Research indicates that abnormal expression or heightened activity ...

6 天之前 · Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium handling, and hypertrophic responses. PDE4 provides spatial and temporal precision to cAMP signalling, particularly under β-adrenergic stimulation, through its compartmentalised activity in subcellular nanodomains, including the sarcoplasmic ...

The phosphodiesterase 4 (PDE4) enzyme plays a crucial role in the central nervous system (CNS). It is extensively expressed in mammalian brain, where it regulates intracellular cyclic adenosine monophosphate (cAMP) levels. Dysregulation of PDE4 and cAMP balance is associated with various neurodegene …

2020年10月1日 · The current review summarises data on the structure and localization and the role of PDE4 and PDE4Is in key molecular signalling pathways in brain. The therapeutic potential of PDE4 inhibitors in various neurological disorders and the data on the on-going clinical trials on PDE4Is for treating neurological disorders is also presented.