解码肺纤维化，探索PDE4B抑制剂作用机制之旅！ - 腾讯网
2024年12月30日 · 磷酸二酯酶4（PDE4）是cAMP主要的降解酶，抑制PDE4具有改善肺纤维化的潜力 3。 本文特邀中国医科大学附属第一医院于娜教授带大家深入了解肺纤维化的发病机制以 …
PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF ...
Phosphodiesterase (PDE)4 inhibitors, by preventing the breakdown of cAMP, can inhibit fibroblast functions and may be able to mitigate tissue remodeling. Transforming growth factor (TGF) …
Phosphodiesterase 4 inhibition reduces lung fibrosis following targeted ...
2018年6月27日 · The phosphodiesterase 4 (PDE4) inhibitors, approved for the treatment of chronic obstructive pulmonary disease, harbor therapeutic potential for pulmonary fibrosis by …
Expression and Activity of Phosphodiesterase Isoforms during …
2009年11月11日 · Most importantly, treatment of TGF-β1 stimulated epithelial cells with the PDE4-selective inhibitor rolipram or PDE4 small interfering RNA potently inhibited EMT …
Overexpression of PDE4D in mouse liver is sufficient to trigger …
2022年1月1日 · Together, the conclusions indicated that PDE4D plays an important role in the pathogenesis of NAFLD and associated hypertension via activation of CD36-TGF-β1 signaling …
The PDE4 Inhibitors Roflumilast and Rolipram Modulate Fibroblast ...
2006年3月17日 · PDE4 inhibition attenuates TGF-β1 stimulation of fibroblast chemotaxis and collagen gel contraction. Two related mechanisms appear to be involved: ( 1 ) potentiation of …
Regulatory pathways and therapeutic potential of PDE4 in liver ...
2024年5月15日 · Phosphodiesterase 4 (PDE4), crucial in regulating the cyclic adenosine monophosphate (cAMP) signaling pathway, significantly impacts liver pathophysiology. This …
A novel phosphodiesterase 4 inhibitor, AA6216, reduces …
2020年10月15日 · We found that AA6216 significantly inhibited TGF-β1 production by THP-1 cells. It also significantly suppressed TNF-α production by alveolar macrophages from patients …
Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast ...
2024年12月23日 · This study is the first to (i) demonstrate the expression of PDE1, PDE7 and PDE8 in TA-derived fibroblasts, (ii) show that selective PDE4 inhibition can prevent TGF-β1 …
Phosphodiesterase 4B inhibition: a potential novel strategy for ...
Phase I and II trials of a novel PDE4B inhibitor in patients with idiopathic pulmonary fibrosis have shown promising results, stabilising pulmonary function measured by change in forced vital …