PDE5 is an enzyme that accepts cGMP and breaks it down. Sildenafil, vardenafil and tadalafil are inhibitors of this enzyme, which bind to the catalytic site of PDE5. Both inhibitors bind with high affinity and specificity, and cGMP-binding to the allosteric sites stimulates binding of PDE5 inhibitors at the catalytic site.

2021年2月1日 · Phosphodiesterase 5 (PDE5) is one of the most well-studied phosphodiesterases (PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated activation of the soluble guanylyl cyclase.

pde5:分布于心脏、血小板、血管平滑肌、脑、肾、肺和骨骼肌;其主要作用包括调节血管收缩，尤其是阴茎和肺部血管的舒缩，同时通过调节 no-cgmp 信号系统调节血小板聚集等；

第五型磷酸二酯酶抑制劑（phosphodiesterase type 5 inhibitor）也稱為PDE5抑制剂，是一種抑制 第五型環磷酸鳥苷特異性磷酸二酯酶 （ 英语 ： cGMP-specific_phosphodiesterase_type_5 ） 對血管內壁平滑肌細胞中的環磷酸鳥苷分解作用的藥物 [1] 。

The phosphodiesterases type 5 (PDE5) are catalytic enzymes converting the second messenger cyclic guanosine monophosphate (cGMP) to 5’ GMP. While intracellular cGMP reduction is associated with several detrimental effects, cGMP stabilization associates with …

磷酸二酯酶 5a，cgmp 特异性： 该基因编码的蛋白可启动 3',5'-环状核苷酸磷酸二酯酶活性和 cgmp 结合活性。参与 map 激酶活性的正向调节；调节肌肉系统过程；和放松心肌。

2023年1月20日 · Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitr …

PDE5 is a key enzyme involved in the regulation of cGMP-specific signaling pathways in normal physiological processes such as smooth muscle contraction and relaxation. For this reason, inhibition of the enzyme can alter those pathophysiological conditions associated with a lowering cGMP level in tis …

磷酸二酯酶5（phosphodiesterase 5，PDE5）抑制剂通过阻断环磷酸鸟苷（cyclic guanosine monophosphate，cGMP）的分解，使包括一氧化氮（nitric oxide，NO）在内的血管舒张介质作用延长，从而导致阴茎和肺的血管舒张。

Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide–driven activation of the soluble guanylyl cyclase.